Ignite Creation Date:
2024-05-05 @ 10:06 PM
Last Modification Date:
2024-10-26 @ 10:14 AM
Study NCT ID:
NCT01035242
Status:
COMPLETED
Last Update Posted:
2015-03-25
First Post:
2009-12-17
Brief Title:
Association Splitting in Obsessive-Compulsive Disorder OCD
Sponsor:
Universitätsklinikum Hamburg-Eppendorf
Organization:
Universitätsklinikum Hamburg-Eppendorf
Study Overview
Official Title:
Association Splitting Compared With Cognitive Remediation CR in Obsessive-compulsive Disorder OCD a Randomized Controlled Trial
Status:
COMPLETED
Status Verified Date:
2015-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Over a period of 3 weeks association splitting is compared to cognitive remediation CogPack training as an add-on intervention to cognitive-behavioral therapy CBT Blind to treatment assignment both groups are assessed before intervention and eight weeks as well as six months later with the Yale-Brown Obsessive Compulsive Scale Y-BOCS the Obsessive-Compulsive Inventory OCI-R and cognitive tests OCD severity as measured by the Y-BOCS total score serves as the primary outcome parameter It is assumed that association splitting will improve OCD severity to a greater extent than cognitive remediation
Detailed Description:
Association splitting is a new cognitive technique which aims at reducing obsessive thoughts It draws upon the so-called fan effect of associative priming Transposing this principle to the treatment of obsessive-compulsive disorder OCD we hypothesized that the sprouting of new and the strengthening of existing neutral associations to core OCD cognitions will reduce their fear-evoking properties by depriving the chain of OCD-related cognitions of associative strength Patients with OCD are randomly allocated to either associations splitting AS or cognitive remediation CogPack training Blind to treatment assignment both groups are assessed before intervention and eight weeks as well as six months later with the Yale-Brown Obsessive Compulsive Scale Y-BOCS the Obsessive-Compulsive Inventory OCI-R and cognitive tests OCD severity derived from the Y-BOCS and the OCI-R serves as the main outcome parameters We also explore if AS changes the OCD-related semantic networks with cognitive tasks It is assumed that association splitting will improve OCD severity to a greater extent than CogPack training
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None