Ignite Creation Date:
2024-05-05 @ 10:06 PM
Last Modification Date:
2024-10-26 @ 10:13 AM
Study NCT ID:
NCT01021449
Status:
COMPLETED
Last Update Posted:
2013-09-12
First Post:
2009-11-25
Brief Title:
Epigenetic Regulation of BDNF in Schizophrenia
Sponsor:
Chang Gung Memorial Hospital
Organization:
Chang Gung Memorial Hospital
Study Overview
Official Title:
Epigenetic Regulation of BDNF and TrK B in Schizophrenic Patients
Status:
COMPLETED
Status Verified Date:
2013-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this proposal we will 1 detect the associations between BDNF and Trk B gene DNA methylation histone modification psychotic symptoms obesity suicide and antipsychotic drug responses in Taiwanese patients 2 discuss the possible mechanisms of epigenetic regulation of BDNF and Trk B in schizophrenia patients
Detailed Description:
A total 160 subjects 80 subjects every year including 40 healthy controls and 40 schizophrenia patients will be recruited during a 2-year period The first year the baseline data of BDNF and Trk B DNA methylation protein and mRNA levels in all subjects will be collected and the following 1 months data will also be collected in schizophrenia with antipsychotic drug treatments The second year the baseline data of BDNF and Trk B histone modification in all subjects will be collected
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None