Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00042445
Status:
COMPLETED
Last Update Posted:
2006-09-04
First Post:
2002-07-30
Brief Title:
Brain Neoplasms Leukemia and Petrochemical Exposures
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2006-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to examine the association of exposure to air contaminants PAH VOC emitted from the petrochemical industries specific genetic polymorphisms P4501A1 MspI exon 7 and GSTM1 T1 of study subjects and their parents and the risks of brain tumors and leukemia among children and youths in metropolitan Kaohsiung southern Taiwan
Detailed Description:
Brain tumors and leukemia are the most common malignancies among children and adolescents in the US Adequate information on the role of inherited genetic susceptibility and environmental exposures in the development of neoplasms in children and adolescents is lacking In Taiwan four large petrochemical industries are located in the Kaohsiung metropolitan area These facilities are proximal to residential areas because of the high population density in the region Data have shown that the concentrations of ambient polycyclic aromatic hydrocarbons PAH and volatile organic compounds VOC around the petrochemical industries are at least 10 and 2 times respectively higher than those in US industrialized communities Our preliminary case-control study in metropolitan Kaohsiung showed that young residents under age 30 living within 3 kilometers of the vicinity of petrochemical industries have a 60 fold increase in brain neoplasms and a 29 fold increase in leukemia The purpose of this proposal is to examine the association of exposure to air contaminants PAH and VOC emitted from the petrochemical industries specific genetic polymorphisms P4501A1 MspI exon 7 and GSTM1 T1 from study subjects and their parents and the risks of brain tumors and leukemia among children and youths in metropolitan Kaohsiung Our hypothesis is that there is an increased risk of brain tumors and leukemia in patients with high cumulative exposure to these hazards and that heritable polymorphisms in several genes modify this association In addition to an independent association of environmental and genetic factors with brain neoplasms and leukemia we hypothesize that there is greater risk associated with the presence of combined environmental exposure and the high risk genotype Also we will assess the role of parental genetic polymorphisms in the development of cancer in their siblings This proposed study uses an environmental molecular epidemiologic approach utilizing prospective enrollment of a cohort of brain tumor and leukemia subjects in a population-based case-control design This proposal is responsive to the recommendation of the National Research Council that risk assessment and public health policy pay special attention to the protection of children
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None