Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001666
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Transcranial Magnetic Stimulation for the Treatment of Poorly Controlled Partial Epilepsy
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Drug Refractory Partial Epilepsy A Therapeutic Trial With Transcranial Magnetic Stimulation
Status:
COMPLETED
Status Verified Date:
2002-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Transcranial Magnetic Stimulation TMS is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function It is very useful when studying the areas of the brain related to motor activity motor cortex corticospinal tract and corpus callosum
Epilepsy is a condition associated with seizures as a result of an over excitable cerebral cortex Despite the introduction of several new antiepileptic medications less than half of the patients diagnosed with partial epilepsy are well controlled However studies have shown that non-invasive stimulation of the brain can decrease the excitability of the cerebral cortex
Researchers are interested in the potential therapeutic effects of TMS on patients with epilepsy that have responded poorly to standard medication This study will use TMS to decrease the excitability of the areas of the brain responsible for seizures
Epilepsy is a condition associated with seizures as a result of an over excitable cerebral cortex Despite the introduction of several new antiepileptic medications less than half of the patients diagnosed with partial epilepsy are well controlled However studies have shown that non-invasive stimulation of the brain can decrease the excitability of the cerebral cortex
Researchers are interested in the potential therapeutic effects of TMS on patients with epilepsy that have responded poorly to standard medication This study will use TMS to decrease the excitability of the areas of the brain responsible for seizures
Detailed Description:
The purpose of this protocol is to study the effects of transcranial magnetic stimulation TMS at 1 Hz on the excitability of the seizure focus in patients with poorly controlled epilepsy refractory to pharmacological treatments 1 Hz TMS is a rate proven to induce long term depression in animal models and reported to decrease the excitability of both human and animal cerebral cortex
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 97-N-0092 | None | None | None |