Ignite Creation Date:
2024-05-05 @ 10:04 PM
Last Modification Date:
2024-10-26 @ 10:13 AM
Study NCT ID:
NCT01022333
Status:
UNKNOWN
Last Update Posted:
2009-12-01
First Post:
2009-11-26
Brief Title:
The Potential for Oral Diindolylmethane DIM Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers
Sponsor:
Womens College Hospital
Organization:
Womens College Hospital
Study Overview
Official Title:
The Potential for Oral DIM Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers
Status:
UNKNOWN
Status Verified Date:
2009-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Women with a BRCA1 mutation face a lifetime risk of breast cancer of approximately 70 and a lifetime risk of ovarian cancer of approximately 40 A number of potential anti-cancer nutrients have been proposed however it is important that diet supplements be evaluated prior to general recommendation
The risk of breast and ovarian cancer in carriers of a BRCA1 mutation might be lowered by some nutritional supplements For example green tea broccoli and vitamin D are of potential interest One dietary supplement that is thought to have potential for BRCA1 carriers is diindolylmethane DIM which is an active ingredient in broccoli and other green vegetables DIM - is found in vegetables like broccoli and is available as a supplement in health food stores The investigators think that DIM may increase the production of the normal copy of BRCA1 and offset the effect of the mutation
The purpose of this study is to determine that there is a potential for oral DIM supplementation to result in the increased production of the BRCA1 protein in BRCA1 mutation carriers The results of the study will also serve as an evaluation of the current use and success of preventive strategies for BRCA1 mutation carriers
The risk of breast and ovarian cancer in carriers of a BRCA1 mutation might be lowered by some nutritional supplements For example green tea broccoli and vitamin D are of potential interest One dietary supplement that is thought to have potential for BRCA1 carriers is diindolylmethane DIM which is an active ingredient in broccoli and other green vegetables DIM - is found in vegetables like broccoli and is available as a supplement in health food stores The investigators think that DIM may increase the production of the normal copy of BRCA1 and offset the effect of the mutation
The purpose of this study is to determine that there is a potential for oral DIM supplementation to result in the increased production of the BRCA1 protein in BRCA1 mutation carriers The results of the study will also serve as an evaluation of the current use and success of preventive strategies for BRCA1 mutation carriers
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None