Ignite Creation Date:
2024-05-05 @ 10:04 PM
Last Modification Date:
2024-10-26 @ 10:13 AM
Study NCT ID:
NCT01023607
Status:
COMPLETED
Last Update Posted:
2013-09-11
First Post:
2009-12-01
Brief Title:
Evaluation of Statin-induced Lipid-rich Plaque Progression by Optical Coherence Tomography OCT Combined With Intravascular Ultrasound IVUS
Sponsor:
Harbin Medical University
Organization:
Harbin Medical University
Study Overview
Official Title:
Evaluation of Statin-induced Lipid-rich Plaque Progression by Optical Coherence Tomography OCTCombined With Intravascular Ultrasound IVUS
Status:
COMPLETED
Status Verified Date:
2013-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Many trials suggested that lipid lowering therapy could significantly reduce cardiovascular events Enhancing stability of vulnerable plaque is probably the main reason by which statins reduce adverse coronary events The size of lipid core and the fibrous cap thickness FCT are the major determinants of plaque vulnerability So it is very important to accurately evaluate changes in plaque after stains therapy
Previous reports suggested that intensive lipid lowering therapy provide more significantly clinical benefit compared with moderate lipid lowering therapySuch benefit may contribute to the changes in following parameters FCT lipid arcquadrants TCFA macrophage plaque disruption and thrombus measured by OCT and plaque burden and remodeling index by IVUS
Current intravascular imaging modalities such as optical coherence tomography OCT and intravascular ultrasound IVUS can provide in vivo quantitative and qualitative information of coronary plaques However there were few studies aimed at monitoring the progression of coronary plaques in patients receiving statin therapy by OCT combined with IVUS
Therefore the study we designed were to compare the effect of the rosuvastatin 10mg atorvastatin 20mg and atorvastatin 60mg treatment on the changes in FCT and lipid core arc by OCT and plaque burden by IVUS of coronary atherosclerotic plaques
Previous reports suggested that intensive lipid lowering therapy provide more significantly clinical benefit compared with moderate lipid lowering therapySuch benefit may contribute to the changes in following parameters FCT lipid arcquadrants TCFA macrophage plaque disruption and thrombus measured by OCT and plaque burden and remodeling index by IVUS
Current intravascular imaging modalities such as optical coherence tomography OCT and intravascular ultrasound IVUS can provide in vivo quantitative and qualitative information of coronary plaques However there were few studies aimed at monitoring the progression of coronary plaques in patients receiving statin therapy by OCT combined with IVUS
Therefore the study we designed were to compare the effect of the rosuvastatin 10mg atorvastatin 20mg and atorvastatin 60mg treatment on the changes in FCT and lipid core arc by OCT and plaque burden by IVUS of coronary atherosclerotic plaques
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None