Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00046670
Status:
COMPLETED
Last Update Posted:
2014-03-05
First Post:
2002-09-30
Brief Title:
Sleep Disordered Breathing APOE and Lipid Metabolism
Sponsor:
Stanford University
Organization:
Stanford University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2014-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine the relationship between obstructive sleep apnea and lipid metabolism
Detailed Description:
BACKGROUND
Recent findings suggest interrelationships between obstructive sleep apnea lipid metabolism and neurodegeneration Apolipoprotein E epsilon4 APOE e4 a genetic marker linked to increased cardiovascular disease CVD risk and Alzheimers disease AD is associated with a two fold increased risk of sleep disordered breathing SDB and an increase in severity of apnea symptoms Preliminary data suggest that this association is stronger between the ages of 50 and 65 Other experiments suggest dysregulated leptin levels in obstructive sleep apnea OSA Taken together these findings suggest common pathophysiological mechanisms involving dysregulated lipid metabolism in OSA An understanding of these mechanisms is essential for the prevention and treatment of SDB
DESIGN NARRATIVE
Using casecontrol and family designs the study 1 extends the finding that apolipoprotein E epsilon4 APOE e4 increases the risk of sleep apnea in the general population 2 examines if polymorphisms in other genes regulating lipid levels are associated with sleep apnea 3 studies the relationship between lipid regulatory gene polymorphisms lipid profile LDL- cholesterol HDL-cholesterol triglycerides plasma leptin and other lipid regulatory hormones and sleep apnea levels
T
Recent findings suggest interrelationships between obstructive sleep apnea lipid metabolism and neurodegeneration Apolipoprotein E epsilon4 APOE e4 a genetic marker linked to increased cardiovascular disease CVD risk and Alzheimers disease AD is associated with a two fold increased risk of sleep disordered breathing SDB and an increase in severity of apnea symptoms Preliminary data suggest that this association is stronger between the ages of 50 and 65 Other experiments suggest dysregulated leptin levels in obstructive sleep apnea OSA Taken together these findings suggest common pathophysiological mechanisms involving dysregulated lipid metabolism in OSA An understanding of these mechanisms is essential for the prevention and treatment of SDB
DESIGN NARRATIVE
Using casecontrol and family designs the study 1 extends the finding that apolipoprotein E epsilon4 APOE e4 increases the risk of sleep apnea in the general population 2 examines if polymorphisms in other genes regulating lipid levels are associated with sleep apnea 3 studies the relationship between lipid regulatory gene polymorphisms lipid profile LDL- cholesterol HDL-cholesterol triglycerides plasma leptin and other lipid regulatory hormones and sleep apnea levels
T
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL071515 | NIH | None | httpsreporternihgovquickSearchR01HL071515 |