Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00045773
Status:
COMPLETED
Last Update Posted:
2017-10-31
First Post:
2002-09-09
Brief Title:
Treatment Outcome of Vascular Depression
Sponsor:
University of Pennsylvania
Organization:
University of Pennsylvania
Study Overview
Official Title:
Treatment Outcome of Vascular Depression
Status:
COMPLETED
Status Verified Date:
2017-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This 12-week study will evaluate the effectiveness of sertraline Zoloft for treatment of depression associated with small vascular lesions in the brain vascular depression
Detailed Description:
Major late life depression LLD is an important health problem with a large and growing number of affected individuals A significant subset of patients with LLD particularly those with vascular depression have abnormalities in certain parts of the brain that are evident on MRI scans and may be associated with poor acute and long-term response to antidepressant treatment Studies have also indicated that LLD patients frequently have frontal lobe dysfunction A longitudinal study with the antidepressant nortriptyline has demonstrated that frontal lobe dysfunction is associated with poor acute response and a greater risk for recurrence of LLD However it is not known if this finding applies to other antidepressants This study will be the first clinical trial to simultaneously test the effects of specific brain and psychological factors on course of response remission rate and other measures of health outcomes in people with LLD
Participants are treated with sertraline for 12 weeks During this period participants undergo cognitive testing MRI electrocardiogram EKG and laboratory tests Study visits occur every 2 weeks
Participants are treated with sertraline for 12 weeks During this period participants undergo cognitive testing MRI electrocardiogram EKG and laboratory tests Study visits occur every 2 weeks
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01MH060697 | NIH | None | None |
| DATR A4-GPX | US NIH GrantContract | None | httpsreporternihgovquickSearchR01MH060697 |