Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00043238
Status:
COMPLETED
Last Update Posted:
2015-04-14
First Post:
2002-08-07
Brief Title:
Mohawk Culture Behavior Toxicant Exposure and Health
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
Mohawk Culture Behavior Toxicant Exposure and Health
Status:
COMPLETED
Status Verified Date:
2015-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine the pathways between Mohawk cultural identification and specific behaviors related to pollutant exposure and determine the effects of these factors and the pollutant exposure on physiologically and socially significant outcomes
Detailed Description:
Considerable concern now exists over possible effects on human physical and psychological development of endocrine disrupting environmental contaminants such as polychlorinated biphenyls PCBs Native American communities are particularly at risk owing to subsistence systems and a cultural ethos involving greater contact with the physical environment The proposed study follows-up 220 Mohawk adolescents aged 17-21 years who participated in a previous study when they were 10-16 years old All adolescents are members of the Mohawk Nation at Akwesasne which is located on the St Lawrence River and is adjacent to hazardous waste sites where PCBs have contaminated the local ecology The investigation examines the interrelationship between Mohawk cultural identity traditional Mohawk customs behaviors related to toxicant exposure and current toxicant burden Serum level of PCBs will be assessed by congener specific analysis The study will determine the relationship of congeners and their hydroxylated metabolites to thyroid function levels of triiodothyronine free triiodothyronine thyroxine free thyroxine thyrotropin and anti-thyroid antibodies and 2 psychosocial outcomes including school behavior and performance hyperactivity and adaptation to the community Data gathered for the past study will be employed to assess variation in metabolism of PCBs as well as how earlier measures of cognition and hyperactivity relate to 17 year old psychosocial outcomes Variation in susceptibility to PCB effects will be determined by examining the effects of concurrent toxicant exposure hexachlorobenzene Mirex dichlorodiphenyldichloroethene lead diet and indicators of PCB metabolism on the focal measures of adult functioning The proposed study will clarify the causal pathways between culturally identifying behavior PCB exposure and body burden thyroid functioning cognitive functioning social behavior and school functioning while identifying activities that are important to maintain cultural identify and unrelated to exposure
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None