Ignite Creation Date:
2024-05-05 @ 9:57 PM
Last Modification Date:
2024-10-26 @ 10:11 AM
Study NCT ID:
NCT00990275
Status:
COMPLETED
Last Update Posted:
2023-09-06
First Post:
2009-10-02
Brief Title:
Alcohol Exposure and Airway Hyperresponsiveness
Sponsor:
University of Nebraska
Organization:
University of Nebraska
Study Overview
Official Title:
Alcohol Exposure and Airway Hyperresponsiveness
Status:
COMPLETED
Status Verified Date:
2023-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Alcohol has consequences including increased risk for upper respiratory tract infections pneumonia acute respiratory distress syndrome ARDS and alcohol-induced asthma The investigators have established that airways are specifically impacted by alcohol exposure because the airways are heavily exposed to the vapor phase of alcohol during drinking These preliminary studies demonstrate that brief alcohol administration significantly attenuates airway hyperresponsiveness AHR in a mouse model leading to the hypothesis that alcohol exposure modifies airway hyperresponsiveness through a cAMPNO- dependent mechanism
Detailed Description:
Alcohol has well-established consequences in the lung including increased risk for upper respiratory tract infections pneumonia and acute respiratory distress syndrome ARDS There have even been a few reports of alcohol-induced asthma Data from the investigators laboratory have established that the airways are specifically impacted by alcohol exposure Because the airways are heavily exposed to the vapor phase of alcohol during drinking and airway motor tone is modulated by cAMP the investigators speculated that airway bronchial motor function would be altered in mice fed alcohol The investigators preliminary studies demonstrate that brief alcohol administration significantly attenuates airway hyperresponsiveness AHR in a mouse model This novel finding has led us to hypothesize that
Alcohol exposure modifies airway hyperresponsiveness through a cAMPNO- dependent mechanism
Alcohol exposure modifies airway hyperresponsiveness through a cAMPNO- dependent mechanism
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1F32AA017024-01 | NIH | None | httpsreporternihgovquickSearch1F32AA017024-01 |