Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00047944
Status:
COMPLETED
Last Update Posted:
2017-10-06
First Post:
2002-10-22
Brief Title:
MRI Study of Brain Activity and Risk for Depression in Adolescents
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Neural Circuitry and Risk for Depression in Adolescents A Study Using Functional Magnetic Resonance Imaging
Status:
COMPLETED
Status Verified Date:
2016-10-27
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Anxiety in children of parents with major depressive disorder MDD poses a particularly high risk for later-life MDD In adults MDD involves dysfunction in prefrontal brain regions that regulate attention to emotional stimuli These abnormalities i have been found primarily in adults with specific familial forms of MDD ii persist after recovery from MDD and iii relate to anxiety These findings raise the possibility that risk for MDD is tied to dysfunction in prefrontal regions involved in regulation of emotion which possibly manifests as early-life anxiety If this possibility were confirmed in never-depressed adolescents at high risk for MDD the findings would provide key insights into the developmental neurobiology of MDD The goal of this protocol is to study the neural substrate of risk for MDD in young people This protocol tests the hypothesis that adolescents at high risk for MDD by virtue of childhood anxiety and parental history of MDD exhibit dysfunction in prefrontal cortex and amygdala regions involved in emotion regulation This goal will be accomplished through fMRI studies of emotion regulation in high and low-risk adolescents
For this research at-risk adolescents will be recruited from participants in an NIMH-funded extramural study at New York University NYU examining the biology of risk for anxiety and depressive disorders Over a three-year period 45 high-risk probands and 60 low-risk comparisons will be studied including 20 comparisons from the NYU sample and 40 from the Washington DC metropolitan area In the present protocol to be conducted at NIH subjects will undergo volumetric MRI scans to assess structural abnormalities in the prefrontal cortex and medial temporal lobe They will complete a series of four out-of-scanner cognitive tasks and two fMRI-based cognitive tasks that measure modulation of attention to emotional stimuli The fMRI tasks are hypothesized to differentially engage the prefrontal cortex and amygdala in low vs high risk subjects These tasks will be used to test the hypothesis that at-risk individuals exhibit enhanced amygdala and reduced prefrontal activation on the fMRI emotionattention tasks
For this research at-risk adolescents will be recruited from participants in an NIMH-funded extramural study at New York University NYU examining the biology of risk for anxiety and depressive disorders Over a three-year period 45 high-risk probands and 60 low-risk comparisons will be studied including 20 comparisons from the NYU sample and 40 from the Washington DC metropolitan area In the present protocol to be conducted at NIH subjects will undergo volumetric MRI scans to assess structural abnormalities in the prefrontal cortex and medial temporal lobe They will complete a series of four out-of-scanner cognitive tasks and two fMRI-based cognitive tasks that measure modulation of attention to emotional stimuli The fMRI tasks are hypothesized to differentially engage the prefrontal cortex and amygdala in low vs high risk subjects These tasks will be used to test the hypothesis that at-risk individuals exhibit enhanced amygdala and reduced prefrontal activation on the fMRI emotionattention tasks
Detailed Description:
Parental history of major depressive disorder poses a particularly high risk for later-life MDD In adults MDD involves dysfunction in subcortical brain regions related to emotional responsiveness such as the amygdala and in cortical brain regions that interface cognitive and emotional processes These abnormalities i have been found primarily in adults with specific familial forms of MDD ii persist after recovery from MDD and iii relate to anxiety These findings raise the possibility that risk for MDD is tied to dysfunction in emotional circuits themselves or in prefrontal regions involved in regulation of emotion If this possibility were confirmed in never-depressed adolescents at high risk for MDD the findings would provide key insights into the developmental neurobiology of MDD The goal of this protocol is to study the neural substrate of risk for MDD in young people This protocol tests the hypothesis that adolescents at high risk for MDD by virtue of parental history of MDD exhibit dysfunction in prefrontal cortex amygdala and other subcortical regions involved in emotion and emotion regulation This goal will be accomplished through fMRI studies of edmotion provocation in high and low-risk adolescents
For this research at-risk adolescents will be recruited from participants in NIMH-funded extramural studies at New York University Brown University and Columbia University examining the biology of risk for anxiety and depressive disorders Over a three-year period data on each measure of interest will be obtained in 100 high-risk probands and 100 low-risk comparisons In addition a sub-set of parents of these adolescents n100 also will be studied using identical procedures In the present protocol to be conducted at NIH subjects will undergo volumetric MRI scans to assess structural abnormalities in the prefrontal cortex and medial temporal lobe They will complete a series of out-of-scanner cognitive tasks and fMRI-based cognitive tasks Two of these tasks measure modulation of attention to emotional stimuli the third task measures engagement of temporal and prefrontal regions during social interactions For these types of tasks prior studies in adolescents with ongoing mood and anxiety disorders demonstrate hypothesized abnormalities in brain engagement The current study is designed to examine the degree to which comparable findings emerge in unaffected adolescents at risk for mood and anxiety disorders
For this research at-risk adolescents will be recruited from participants in NIMH-funded extramural studies at New York University Brown University and Columbia University examining the biology of risk for anxiety and depressive disorders Over a three-year period data on each measure of interest will be obtained in 100 high-risk probands and 100 low-risk comparisons In addition a sub-set of parents of these adolescents n100 also will be studied using identical procedures In the present protocol to be conducted at NIH subjects will undergo volumetric MRI scans to assess structural abnormalities in the prefrontal cortex and medial temporal lobe They will complete a series of out-of-scanner cognitive tasks and fMRI-based cognitive tasks Two of these tasks measure modulation of attention to emotional stimuli the third task measures engagement of temporal and prefrontal regions during social interactions For these types of tasks prior studies in adolescents with ongoing mood and anxiety disorders demonstrate hypothesized abnormalities in brain engagement The current study is designed to examine the degree to which comparable findings emerge in unaffected adolescents at risk for mood and anxiety disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-M-0014 | None | None | None |