Ignite Creation Date:
2024-05-05 @ 9:55 PM
Last Modification Date:
2024-10-26 @ 10:12 AM
Study NCT ID:
NCT00999934
Status:
UNKNOWN
Last Update Posted:
2017-01-11
First Post:
2009-10-21
Brief Title:
Neural Mechanisms Engaged in Control of Eye Movements
Sponsor:
Meir Medical Center
Organization:
Meir Medical Center
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2016-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of eye movements is to ensure clear optimal vision In order to see clearly images must be held steady on the retina Best visual acuity is achieved when the image of the object of interest is brought to and held on the fovea of the retina Two main types of eye movements are responsible for that those that keep images stable on the retina gaze holding mechanisms and those that change the line of sight gaze shifting mechanisms Several functional classes of eye movements have been defined each has distinctive physiological properties that suit best to its particular task Thus vestibular and optokinetic eye movements hold images of the seen world steady on the retina during perturbations of the head Saccades are rapid eye movements that bring the image of an object of interest detected in the periphery of vision onto the fovea where it can be seen best Smooth pursuit eye movements place the images of a moving target close to fovea Vergence eye movements place the images of a single object simultaneously onto both foveae
Each functional class of eye movements relies on a different neural substrate The clinical significance of it is that impairment of a specific class of eye movement points to involvement of distinct structures or pathways within the brain Thus abnormalities of ocular motility are often the clue to the anatomical localization of neurological disorders
Significance This study will contribute to understand how the brain governs production of eye movements and provide better insight on interaction between sensory visual and motor eye movement system ie sensory-motor interaction It will also contribute to identify pathophysiological mechanisms underlying human diseases and will improve the investigators ability to diagnose and encourage development of new therapeutic strategies
Methods The investigators will measure eye and head movements using the magnetic scleral search coil technique The magnetic search coil technique is the most sensitive and accurate technique used in modern ocular motor and vestibular research for measuring horizontal vertical and torsional eye movements The coils are easy to apply and well tolerated over a wearing period of up to 45 minutes per recording session
Population A grand total of about 250 individuals normal subjects and patients will be recruited for the study Patients will be recruited from the in- and out-patients of the Neurology and Neuro-ophthalmology services of Meir Medical Center Healthy normal subjects will be recruited from faculty and staff of Meir Medical Center
Criteria for inclusionexclusion The investigators will study patients with neurological disorders causing abnormal eye movements Degenerative CNS diseases extrapyramidal disorders Spino-cerebellar ataxias Cerebrovascular diseases demyelinating diseases Ocular motor and vestibular palsies Mitochondrial and other ocular myopathies Only patients who are medically stable and are able to give informed consent will be included in the study Criteria for excluding subjects will include eye disease such as corneal or scleral abrasion or disease glaucoma refractive errors greater than 2 diopters and concurrent medication with CNS-active agents
Each functional class of eye movements relies on a different neural substrate The clinical significance of it is that impairment of a specific class of eye movement points to involvement of distinct structures or pathways within the brain Thus abnormalities of ocular motility are often the clue to the anatomical localization of neurological disorders
Significance This study will contribute to understand how the brain governs production of eye movements and provide better insight on interaction between sensory visual and motor eye movement system ie sensory-motor interaction It will also contribute to identify pathophysiological mechanisms underlying human diseases and will improve the investigators ability to diagnose and encourage development of new therapeutic strategies
Methods The investigators will measure eye and head movements using the magnetic scleral search coil technique The magnetic search coil technique is the most sensitive and accurate technique used in modern ocular motor and vestibular research for measuring horizontal vertical and torsional eye movements The coils are easy to apply and well tolerated over a wearing period of up to 45 minutes per recording session
Population A grand total of about 250 individuals normal subjects and patients will be recruited for the study Patients will be recruited from the in- and out-patients of the Neurology and Neuro-ophthalmology services of Meir Medical Center Healthy normal subjects will be recruited from faculty and staff of Meir Medical Center
Criteria for inclusionexclusion The investigators will study patients with neurological disorders causing abnormal eye movements Degenerative CNS diseases extrapyramidal disorders Spino-cerebellar ataxias Cerebrovascular diseases demyelinating diseases Ocular motor and vestibular palsies Mitochondrial and other ocular myopathies Only patients who are medically stable and are able to give informed consent will be included in the study Criteria for excluding subjects will include eye disease such as corneal or scleral abrasion or disease glaucoma refractive errors greater than 2 diopters and concurrent medication with CNS-active agents
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None