Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00044369
Status:
COMPLETED
Last Update Posted:
2006-09-04
First Post:
2002-08-27
Brief Title:
Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
Increased Testicular Cd2 Infertility With Varicocele a Varicose Vein in the Scrotum
Status:
COMPLETED
Status Verified Date:
2006-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Varicose veins in the scrotum varicocele are responsible for 20 of male infertility in the US Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability Surgical repair or removal of varicocele restores fertility in only 13 of cases The goal of this study is to identify markers that predict the outcome of variocele correction This would offer considerable health cost savings
Based on preliminary findings we will obtain testis biopsies and semen specimens from infertile men with varicocele and prospectively examining the levels of cadmium a toxic metal and expression of genes required for normal sperm function The semen and biopsies will be obtained during clinically dictated procedures Cadmium and gene expression will be compared with response to varicocele repair ie increased sperm production pregnancy
Based on preliminary findings we will obtain testis biopsies and semen specimens from infertile men with varicocele and prospectively examining the levels of cadmium a toxic metal and expression of genes required for normal sperm function The semen and biopsies will be obtained during clinically dictated procedures Cadmium and gene expression will be compared with response to varicocele repair ie increased sperm production pregnancy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None