Ignite Creation Date:
2024-05-05 @ 9:51 PM
Last Modification Date:
2024-10-26 @ 10:10 AM
Study NCT ID:
NCT00970190
Status:
COMPLETED
Last Update Posted:
2014-12-11
First Post:
2009-08-31
Brief Title:
Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate cAMPCalcium Signaling Study
Sponsor:
Greg Davis
Organization:
University of Washington
Study Overview
Official Title:
Olfactory Dysfunction of Rhinosinusitis - cAMPCalcium Signaling Study
Status:
COMPLETED
Status Verified Date:
2014-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
cAMP
Brief Summary:
The study examines the biochemistry underlying human olfaction in both normal and diseased states
The study aims are 1 to determine the levels of cAMP in olfactory tissue from people with chronic rhinosinusitis and other nasal disorders 2 to correlate preoperative olfactory function with cAMP levels from biopsied olfactory tissue 3 to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using calcium imaging and 4 to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using smell-chip technology
The study aims are 1 to determine the levels of cAMP in olfactory tissue from people with chronic rhinosinusitis and other nasal disorders 2 to correlate preoperative olfactory function with cAMP levels from biopsied olfactory tissue 3 to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using calcium imaging and 4 to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using smell-chip technology
Detailed Description:
Subject will be recruited from those scheduled to have endoscopic sinus surgery and similar procedures This study uses the tissue that would normally be discarded during the surgical process The tissue is cultured and frozen for purposes of the following testing
odor detection and signal transduction cyclic adenosine monophosphate and odor detection the role of cAMP in olfactory dysfunction and pheromone detection
Only tissue that would normally be discarded during the course of the surgery will be used The study does not interfere with or change any clinical care
odor detection and signal transduction cyclic adenosine monophosphate and odor detection the role of cAMP in olfactory dysfunction and pheromone detection
Only tissue that would normally be discarded during the course of the surgery will be used The study does not interfere with or change any clinical care
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None