Ignite Creation Date:
2024-05-05 @ 11:26 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00037310
Status:
COMPLETED
Last Update Posted:
2016-07-29
First Post:
2002-05-16
Brief Title:
New CVD Risk Factors for Lowered Cognitive Functioning
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To explore the associations between cognitive functioning and three major cardiovascular disease risk factors high blood pressure high total plasma homocysteine tHcy and ApoE e4 genotype
Detailed Description:
BACKGROUND
Arterial hypertension and high blood pressure HBP are major risk factors for cardiovascular disease CVD and stroke they are also risk factors for lowered cognitive functioning Except for diabetes there have been comparatively few studies of other common risk factors particularly with regard to interrelationships among risk factors which may adversely affect cognitive ability
DESIGN NARRATIVE
The study examines associations between cognitive functioning and three cardiovascular risk factors 1 high blood pressure 2 high total plasma homocysteine tHcy and 3 ApoE e4 genotype These associations are examined cross-sectionally as well as longitudinally using data collected at a follow-up visit of members of a cohort that has been followed for the past 18-19 years Longitudinal data are used to examine both current and change in cognitive functioning Some analyses are prospective eg high blood pressure and change in cognitive functioning while others are cross-sectional eg ApoE e4 and current cognitive functioning or retrospective eg tHcy and change in cognitive functioning Structural equation models are used to examine cross-sectional data in elucidating a general theoretical model Two-stage growth curve analyses and survival analyses are appropriate methods for analyzing the longitudinal data The study includes a very comprehensive set of measures that have already been collected or will be collected during the follow-up visit All potential confounders of the association between the three target predictor variables and the various domains of cognitive functioning appear to have been included in this design
Arterial hypertension and high blood pressure HBP are major risk factors for cardiovascular disease CVD and stroke they are also risk factors for lowered cognitive functioning Except for diabetes there have been comparatively few studies of other common risk factors particularly with regard to interrelationships among risk factors which may adversely affect cognitive ability
DESIGN NARRATIVE
The study examines associations between cognitive functioning and three cardiovascular risk factors 1 high blood pressure 2 high total plasma homocysteine tHcy and 3 ApoE e4 genotype These associations are examined cross-sectionally as well as longitudinally using data collected at a follow-up visit of members of a cohort that has been followed for the past 18-19 years Longitudinal data are used to examine both current and change in cognitive functioning Some analyses are prospective eg high blood pressure and change in cognitive functioning while others are cross-sectional eg ApoE e4 and current cognitive functioning or retrospective eg tHcy and change in cognitive functioning Structural equation models are used to examine cross-sectional data in elucidating a general theoretical model Two-stage growth curve analyses and survival analyses are appropriate methods for analyzing the longitudinal data The study includes a very comprehensive set of measures that have already been collected or will be collected during the follow-up visit All potential confounders of the association between the three target predictor variables and the various domains of cognitive functioning appear to have been included in this design
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL067358 | NIH | None | httpsreporternihgovquickSearchR01HL067358 |