Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00030953
Status:
COMPLETED
Last Update Posted:
2019-12-17
First Post:
2002-02-14
Brief Title:
Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Evaluation of Tourettes Syndrome With Multimetabolite H-Magnetic Resonance Spectroscopy at 3T
Status:
COMPLETED
Status Verified Date:
2015-02-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use magnetic resonance imaging MRI and magnetic resonance spectroscopy MRS of the brain to try to gain a better understanding of the disease process in Tourette s syndrome a neuropsychiatric disorder characterized by motor and vocal tics Tourette s syndrome is also associated with behavioral and emotional disturbances including symptoms of attention deficit hyperactivity disorder ADHD and obsessive-compulsive disorder OCD MRI and MRS show chemical substances in the brain Findings in normal volunteers will be compared with those of patients
Healthy volunteers and patients with Tourette s syndrome 14 years of age and older may be eligible for this study Volunteers will be screened with a medical history and physical and neurological examinations Patients will be screened through NINDS protocol 93-N-0202
Participants will undergo MRI and MRS MRI uses a strong magnetic field and radio waves to visualize brain anatomy and chemistry For this study the subject lies on a stretcher which is moved into a strong magnetic field the MRI scanner Earplugs are worn to muffle loud thumping noises caused by the electrical switching of the radio frequency circuits During the study the subject lies still during each scan for 1 to 8 minutes at a time Total scanning time varies from 20 minutes to 2 hours with most examinations lasting between 45 and 90 minutes The subject can speak through an intercom with the staff member performing the study at all times during the procedure Up to 5 studies may be performed
Healthy volunteers and patients with Tourette s syndrome 14 years of age and older may be eligible for this study Volunteers will be screened with a medical history and physical and neurological examinations Patients will be screened through NINDS protocol 93-N-0202
Participants will undergo MRI and MRS MRI uses a strong magnetic field and radio waves to visualize brain anatomy and chemistry For this study the subject lies on a stretcher which is moved into a strong magnetic field the MRI scanner Earplugs are worn to muffle loud thumping noises caused by the electrical switching of the radio frequency circuits During the study the subject lies still during each scan for 1 to 8 minutes at a time Total scanning time varies from 20 minutes to 2 hours with most examinations lasting between 45 and 90 minutes The subject can speak through an intercom with the staff member performing the study at all times during the procedure Up to 5 studies may be performed
Detailed Description:
OBJECTIVE
The purpose of this study is to obtain a better understanding of the pathophysiology of Tourettes Syndrome TS with nuclear magnetic spectroscopic imaging The basal ganglia have been implicated in the origin of tics and we plan to use spectroscopy to determine whether there is any neuronal degeneration or a decrease in aminobutyric acid GABA within the basal ganglia thalamus or frontal cortex of patients with TS when compared to normal individuals
STUDY POPULATION
This research will be conducted using patients with TS and normal volunteers
DESIGN
Patients and normal volunteers will be scanned with 3 Tesla General Electric GE magnetic resonance imager using magnetic resonance spectroscopy MRS to measure N-acetylaspartate choline creatine lactate and GABA
OUTCOME MEASURES
Concentrations of metabolites will be compared between two groups
The purpose of this study is to obtain a better understanding of the pathophysiology of Tourettes Syndrome TS with nuclear magnetic spectroscopic imaging The basal ganglia have been implicated in the origin of tics and we plan to use spectroscopy to determine whether there is any neuronal degeneration or a decrease in aminobutyric acid GABA within the basal ganglia thalamus or frontal cortex of patients with TS when compared to normal individuals
STUDY POPULATION
This research will be conducted using patients with TS and normal volunteers
DESIGN
Patients and normal volunteers will be scanned with 3 Tesla General Electric GE magnetic resonance imager using magnetic resonance spectroscopy MRS to measure N-acetylaspartate choline creatine lactate and GABA
OUTCOME MEASURES
Concentrations of metabolites will be compared between two groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0128 | None | None | None |