Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00030303
Status:
COMPLETED
Last Update Posted:
2017-04-28
First Post:
2002-02-14
Brief Title:
Vaccine Therapy in Treating Patients With Chronic Myelogenous Leukemia
Sponsor:
UConn Health
Organization:
UConn Health
Study Overview
Official Title:
A Feasibility And Toxicity Study Of Vaccination With HSP70 For The Treatment Of Chronic Myelogenous Leukemia In Chronic Phase
Status:
COMPLETED
Status Verified Date:
2017-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
RATIONALE Vaccines made from a persons white blood cells may make the body build an immune response to kill cancer cells
PURPOSE Phase I trial to study the effectiveness of vaccine therapy in treating patients who have chronic myelogenous leukemia
PURPOSE Phase I trial to study the effectiveness of vaccine therapy in treating patients who have chronic myelogenous leukemia
Detailed Description:
OBJECTIVES
Determine the feasibility of vaccination with autologous heat shock protein 70 in patients with chronic phase chronic myelogenous leukemia
Determine the toxicity of this vaccination in these patients
OUTLINE Patients undergo leukapheresis to obtain peripheral mononuclear cells PMNCs Heat shock protein 70 HSP70 is derived from the autologous PMNCs Patients receive HSP70 intradermally once weekly for 8 weeks
Patients are followed for 2 weeks
Determine the feasibility of vaccination with autologous heat shock protein 70 in patients with chronic phase chronic myelogenous leukemia
Determine the toxicity of this vaccination in these patients
OUTLINE Patients undergo leukapheresis to obtain peripheral mononuclear cells PMNCs Heat shock protein 70 HSP70 is derived from the autologous PMNCs Patients receive HSP70 intradermally once weekly for 8 weeks
Patients are followed for 2 weeks
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NCI-V01-1685 | Registry Identifier | PDQ Physician Data Query | None |
| CDR0000069127 | REGISTRY | None | None |
| UCHC-7659 | None | None | None |