Ignite Creation Date:
2024-05-05 @ 9:47 PM
Last Modification Date:
2024-10-26 @ 10:10 AM
Study NCT ID:
NCT00969930
Status:
UNKNOWN
Last Update Posted:
2011-08-16
First Post:
2009-09-01
Brief Title:
Genetic Association Study Between Single Nucleotide Polymorphisms SNPs and Cognitive Performance in Young Bipolar Type I Patients LICAVALGENE
Sponsor:
University of Sao Paulo
Organization:
University of Sao Paulo
Study Overview
Official Title:
Genetic Association Study Between Single Nucleotide Polymorphisms SNPs and Cognitive Performance in Young Bipolar Type I Patients LICAVALGENE
Status:
UNKNOWN
Status Verified Date:
2009-09
Last Known Status:
ENROLLING_BY_INVITATION
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Licavalgene
Brief Summary:
This is a genetic association study of cognitive impairment in young bipolar disease type I patients without medications in mania depression hypomania or mixed states
Detailed Description:
Introduction
Cognitive impairment in bipolar disease BD patients is common and recent data suggests that it may be an endophenotype of the disease as it differs individually persists during periods of euthymia and co segregates in families of BD patients Cognition is a complex trait and is therefore likely to be underpinned by many genes each with a relatively small effect Performance in each domain of the neuropsychological assessment can be statistically linked to the functional activity of particular protein and by extension to the genetic variants accounting for theses functional differences
Methods
80 patients with BD type I SCID DSM-IV age from 18 to 35 years old currently on mania depression hypomania or mixed state after medication wash out will be submitted to complete neuropsychological evaluation and genotyped for COMT val158met rs165599 -287 rs737865 ApoE epsilon 4 and BDNF val66metand 80 healthy controls
Cognitive impairment in bipolar disease BD patients is common and recent data suggests that it may be an endophenotype of the disease as it differs individually persists during periods of euthymia and co segregates in families of BD patients Cognition is a complex trait and is therefore likely to be underpinned by many genes each with a relatively small effect Performance in each domain of the neuropsychological assessment can be statistically linked to the functional activity of particular protein and by extension to the genetic variants accounting for theses functional differences
Methods
80 patients with BD type I SCID DSM-IV age from 18 to 35 years old currently on mania depression hypomania or mixed state after medication wash out will be submitted to complete neuropsychological evaluation and genotyped for COMT val158met rs165599 -287 rs737865 ApoE epsilon 4 and BDNF val66metand 80 healthy controls
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None