Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00034073
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2002-04-20
Brief Title:
Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Quantitative fMRI in Children and Adults Using Arterial Spin Tagging Techniques
Status:
COMPLETED
Status Verified Date:
2009-04-16
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use magnetic resonance imaging MRI to examine how blood flow to the brain differs at different ages with the brain is at rest and during performance of tasks that involve language memory motor control and sight The study will evaluate the usefulness of MRI in identifying language function and location and may provide information on how the brain develops over time to process brain functions such as language and memory
Healthy normal volunteers in three age groups-children 8-10 adolescents 13-16 and young adults 21-30-may be eligible for this study Participants must be right-handed and be native English speakers Candidates will be screened via a telephone interview and examination by a neurologist
Participants will undergo MRI scanning of the brain during rest or while performing a task designed to test a skill The tasks may involve remembering numbers reading a word tapping fingers or looking at a flashing picture MRI uses a magnetic field and radio waves to produce pictures of the brain For the procedure the subject lies still on a table that is moved into the scanner a cylinder containing the magnet Earplugs are worn to muffle loud noises caused by electrical switching of radio frequency circuits used in the scanning process Adults may spend as long as 90 minutes in the scanner usually less than 45 minutes For children the time is less than 75 minutes-usually 30 to 40 minutes Participants may be asked to repeat the scans up to 5 times in different sessions to test different brain functions or confirm findings
Healthy normal volunteers in three age groups-children 8-10 adolescents 13-16 and young adults 21-30-may be eligible for this study Participants must be right-handed and be native English speakers Candidates will be screened via a telephone interview and examination by a neurologist
Participants will undergo MRI scanning of the brain during rest or while performing a task designed to test a skill The tasks may involve remembering numbers reading a word tapping fingers or looking at a flashing picture MRI uses a magnetic field and radio waves to produce pictures of the brain For the procedure the subject lies still on a table that is moved into the scanner a cylinder containing the magnet Earplugs are worn to muffle loud noises caused by electrical switching of radio frequency circuits used in the scanning process Adults may spend as long as 90 minutes in the scanner usually less than 45 minutes For children the time is less than 75 minutes-usually 30 to 40 minutes Participants may be asked to repeat the scans up to 5 times in different sessions to test different brain functions or confirm findings
Detailed Description:
FMRI using BOLD technique is an indirect and relative measure of neuronal activity and makes comparison among age groups problematic in light of known age related changes in glucose consumption and resting cerebral blood flow In this study Arterial Spin Tagging techniques will be used to perform quantitative measures of blood flow changes during fMRI tasks Children and adults will perform four tasks primary sensory photic flash primary motor finger tapping and cognitive working memory and semantic decision tasks using parametric block designs to account for developmental performance using imaging parameters that allow quantitative measures of cerebral blood flow response as well as BOLD signal Three age groups will be studied children 8-10 14-16 and young adults 21-28 Data will be analyzed using AFNI to identify activated areas Further analysis will be performed using a region of interest analysis We will compare quantitative measures at optimal performance levels The three experimental age groups will be compared for delta rCBF and extent of activated area for each task The study will determine age dependent changes in blood flow response during cortical activation across ages
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0182 | None | None | None |