Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00038688
Status:
COMPLETED
Last Update Posted:
2009-10-30
First Post:
2002-06-04
Brief Title:
A Study of Peer Education to Prevent HIV Transmission Among Injection Drug Users and Their HIV Risk Contacts
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institute of Allergy and Infectious Diseases NIAID
Study Overview
Official Title:
A Phase III Randomized Study to Evaluate the Efficacy of a Network-Oriented Peer Education Intervention for the Prevention of HIV Transmission Among Injection Drug Users and Their Network Members
Status:
COMPLETED
Status Verified Date:
2006-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Injection drug use is the major mode of HIV transmission in many countries Injection drug users IDUs transmit HIV not only through shared drug injection equipment but also through heterosexual and homosexual transmission and mother-to-child transmission Studies have shown that peer education programs can reduce HIV risk behavior in IDUs However it is not known if reduced HIV risk behavior leads to fewer HIV infections The purpose of this study is to find out if a peer education program can reduce the number of new HIV infections by changing the behavior of IDUs and their HIV risk contacts
Detailed Description:
More than 20 years of research in implementing interventions for IDUs indicate that HIV transmission among these users can be prevented slowed and stopped with the appropriate intervention Intervening early with multiple strategies can prevent epidemic spread and its consequences Even after prevalence has increased substantially prevention interventions can reduce the further spread of HIV in drug-using populations and transmission into other populations Although research results have been promising it is unknown if self-reported behavior change is correlated with reducing rates of HIV transmission This study will determine the efficacy of a peer-educator network-oriented intervention to prevent HIV transmission among substance users and their risk network members IDUs will be recruited using street and community outreach methods in Chiang Mai and Chiang Rai Thailand and in Philadelphia Pennsylvania USA
Individuals at the study clinics will undergo a screening survey and HIV counseling and testing they will return to the clinic to receive their HIV test results post-test counseling and further screening Those who are HIV uninfected meet preliminary eligibility requirements and are willing to participate will be enrolled as index participants Each index participant will be asked to identify and attempt to recruit at least two other people potential network members whom heshe has had sex with or taken drugs with in the 3 months prior to screening Infected and uninfected network members will be eligible for enrollment Index participants will be randomly assigned with their network members to either the intervention group or a control group All participants will receive HIV counseling and regular HIV testing Index participants assigned to the intervention group attend six two-hour peer educator-training sessions over a period of 4 weeks The training sessions focus on skills building and promotion of risk-reducing behaviors A one-hour booster training session is held for index participants after their 6- and 12-month follow-up assessments
The study will last approximately 48 months with enrollment expected to take about 30 months Participants will be followed for a minimum of 18 months and a maximum of 30 months Both index participants and network members have follow-up visits every 6 months at which they will complete surveys designed to assess HIV risk behavior network characteristics the intensity of the intervention delivery and social harms that may be associated with study participation Average network HIV incidence rates will be compared for the two study groups
NOTE as of January 31 2006 the HPTN 037 trial was terminated Participants enrolled in the study will continue to be followed at a reduced number of study visits
Individuals at the study clinics will undergo a screening survey and HIV counseling and testing they will return to the clinic to receive their HIV test results post-test counseling and further screening Those who are HIV uninfected meet preliminary eligibility requirements and are willing to participate will be enrolled as index participants Each index participant will be asked to identify and attempt to recruit at least two other people potential network members whom heshe has had sex with or taken drugs with in the 3 months prior to screening Infected and uninfected network members will be eligible for enrollment Index participants will be randomly assigned with their network members to either the intervention group or a control group All participants will receive HIV counseling and regular HIV testing Index participants assigned to the intervention group attend six two-hour peer educator-training sessions over a period of 4 weeks The training sessions focus on skills building and promotion of risk-reducing behaviors A one-hour booster training session is held for index participants after their 6- and 12-month follow-up assessments
The study will last approximately 48 months with enrollment expected to take about 30 months Participants will be followed for a minimum of 18 months and a maximum of 30 months Both index participants and network members have follow-up visits every 6 months at which they will complete surveys designed to assess HIV risk behavior network characteristics the intensity of the intervention delivery and social harms that may be associated with study participation Average network HIV incidence rates will be compared for the two study groups
NOTE as of January 31 2006 the HPTN 037 trial was terminated Participants enrolled in the study will continue to be followed at a reduced number of study visits
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None