Ignite Creation Date:
2025-12-24 @ 1:38 PM
Ignite Modification Date:
2025-12-27 @ 9:40 PM
Study NCT ID:
NCT06166095
Status:
COMPLETED
Last Update Posted:
2025-03-27
First Post:
2023-09-28
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Dose-Response Effect Exercise and Depression
Sponsor:
University of Central Florida
Organization:
Study Overview
Official Title:
Dose-Response Effect of Exercise on Depression and Brain-Derived Neurotrophic Factor (BDNF) in Sedentary Young Adults
Status:
COMPLETED
Status Verified Date:
2025-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The present study aims to address gaps in the literature by evaluating the objectively measured dose-response relationship between exercise and depression symptoms; examining changes in resting (Brain-derived Neurotrophic Factor) BDNF from baseline to week 10 of an exercise intervention; and assessing varying exercise intensities on enjoyment, affect, and health-related quality of life in sedentary young adult college students.
Detailed Description:
This 10-week randomized single-blind controlled trial will consist of an exercise intervention and attention control condition. A two-week familiarity trial period will be followed by 8 weeks of structured exercise. Objectively measured physical activity will be remotely monitored via Fitbit to examine its effect on depressive symptoms in sedentary young adult college students.
Approximately 48 enrolled college students ages 18 - 25 will be recruited for the proposed study and randomized with a 1:1:1 allocation to one of the following conditions:
1. high-dose (HD) moderate to vigorous physical activity (MVPA) (n=16)
2. moderate-dose (MD moderate to vigorous physical activity (MVPA) (n=16)
3. a walking (W) attention control (n=16)
Approximately 48 enrolled college students ages 18 - 25 will be recruited for the proposed study and randomized with a 1:1:1 allocation to one of the following conditions:
1. high-dose (HD) moderate to vigorous physical activity (MVPA) (n=16)
2. moderate-dose (MD moderate to vigorous physical activity (MVPA) (n=16)
3. a walking (W) attention control (n=16)
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?: