Ignite Creation Date:
2024-05-05 @ 9:44 PM
Last Modification Date:
2024-10-26 @ 10:09 AM
Study NCT ID:
NCT00958113
Status:
COMPLETED
Last Update Posted:
2015-05-28
First Post:
2009-08-11
Brief Title:
Autoimmune Thyroid Disease Genetic Study
Sponsor:
University of Colorado Denver
Organization:
University of Colorado Denver
Study Overview
Official Title:
Autoimmune Thyroid Disease Genetic Study
Status:
COMPLETED
Status Verified Date:
2015-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The hypothesis of this project is that specific genes can be identified that contribute to genetic susceptibility to autoimmune thyroid disease AITD in different populations The specific aim of this project is carry out one or more genomewide association studies GWAS to map and ultimately identify genes that confer susceptibility to AITD AITD consists principally of Hashimotos Thyroiditis HT and Graves Disease GD characterized clinically generally by hypothyroidism and hyperthyroidism respectively Both HT and GD are autoimmune diseases characterized by infiltration of the thyroid by T and B cells that are reactive with thyroid antigens and by the production of thyroid autoantibodies TAB While there is some evidence that there may be genes specific to either GD or HT other genes appear to be common to both and some genes may furthermore be in common to susceptibility to other autoimmune diseases Genes known to play a role in AITD include HLA CTLA4 thyroglobulin TG THSR and CD40 PTPN2 and PTPN22 several of which are also involved in susceptibility to other autoimmune diseases All of these genes interact in a complex manner that has yet to be understood Furthermore it seems clear that relatively few of the genes involved in susceptibility to AITD have thus far been discovered
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None