Ignite Creation Date:
2024-05-05 @ 9:42 PM
Last Modification Date:
2024-10-26 @ 10:08 AM
Study NCT ID:
NCT00943891
Status:
UNKNOWN
Last Update Posted:
2014-01-22
First Post:
2009-07-20
Brief Title:
A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
Sponsor:
National University Hospital Singapore
Organization:
National University Hospital Singapore
Study Overview
Official Title:
A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
Status:
UNKNOWN
Status Verified Date:
2014-01
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 To determine the association between LVD and clinico-pathologic variables in archived colorectal cancer and Nasopharyngeal carcinoma specimens
2 To determine the association between VEGF-C-D expression with COX-2 expression and clinico-pathologic variables in colorectal cancer and Nasopharyngeal carcinoma
3 To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma Lymphangiogenesis and factors modulating lymphangiogenesis are associated with clinico-pathological outcome in Nasopharyngeal carcinoma and colorectal cancer Celecoxib down-regulates lymphangiogenesis Archival colorectal cancer and Nasopharyngeal carcinoma tumor specimens will be obtained from the Department of Pathology To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma the investigators intend to analyze archived specimens collected in a previously conducted study Colorectal tumor and nodal specimens and Nasopharyngeal carcinoma primary will be examined for MVD LVD and growth factor expression using established haematoxylin and eosin and immunohistochemical techniques Quantification of LVD and MVD shall be performed by two pathologists blinded to clinico-pathological variables using standardised methods
2 To determine the association between VEGF-C-D expression with COX-2 expression and clinico-pathologic variables in colorectal cancer and Nasopharyngeal carcinoma
3 To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma Lymphangiogenesis and factors modulating lymphangiogenesis are associated with clinico-pathological outcome in Nasopharyngeal carcinoma and colorectal cancer Celecoxib down-regulates lymphangiogenesis Archival colorectal cancer and Nasopharyngeal carcinoma tumor specimens will be obtained from the Department of Pathology To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma the investigators intend to analyze archived specimens collected in a previously conducted study Colorectal tumor and nodal specimens and Nasopharyngeal carcinoma primary will be examined for MVD LVD and growth factor expression using established haematoxylin and eosin and immunohistochemical techniques Quantification of LVD and MVD shall be performed by two pathologists blinded to clinico-pathological variables using standardised methods
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None