Ignite Creation Date:
2024-05-05 @ 9:41 PM
Last Modification Date:
2024-10-26 @ 10:08 AM
Study NCT ID:
NCT00940082
Status:
UNKNOWN
Last Update Posted:
2011-09-13
First Post:
2009-07-14
Brief Title:
The Cardiopathic Features and Analysis of Risk Factors in the Elderly Diabetic
Sponsor:
Third Military Medical University
Organization:
Third Military Medical University
Study Overview
Official Title:
The Cardiopathic Features and Analysis of Risk Factors in the Elderly Diabetic
Status:
UNKNOWN
Status Verified Date:
2011-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Objectives To investigate the cardiac condition of the diabetic patients in our hospital in order to seek for the new diagnostic method of warning its cardiovascular complications in early times
Methods 317 diabetic patients in our hospital from January in 2004 to July in 2008 were divided into 2 groups group A 106 patients whose age ranged from 31-59 and group B 211 patients whose age ranged from 60-90 The height weight blood glucose glycosylated hemoglobin lipid blood pressure course of disease ejection fraction EF fractional shorteningFS diameter of left ventricle in late diastolic stageLVEDd the thickness of the ventricular septaIVSDand the posterior wall of the right ventricle in late diastolic stage LVPWdwere recorded respectively Left ventricular mass index LVMI relative wall thickness RWT were calculated and High-sensitive C-reactive protein HsCRP homocysteine and TNF-α were detected Multifactor logistic regression was made based on the comparison and contrast between all indexes to analyze the correlations between age and the positive indexes
Methods 317 diabetic patients in our hospital from January in 2004 to July in 2008 were divided into 2 groups group A 106 patients whose age ranged from 31-59 and group B 211 patients whose age ranged from 60-90 The height weight blood glucose glycosylated hemoglobin lipid blood pressure course of disease ejection fraction EF fractional shorteningFS diameter of left ventricle in late diastolic stageLVEDd the thickness of the ventricular septaIVSDand the posterior wall of the right ventricle in late diastolic stage LVPWdwere recorded respectively Left ventricular mass index LVMI relative wall thickness RWT were calculated and High-sensitive C-reactive protein HsCRP homocysteine and TNF-α were detected Multifactor logistic regression was made based on the comparison and contrast between all indexes to analyze the correlations between age and the positive indexes
Detailed Description:
Diabetes is one of the commonly seen health hazards in modern times According to statistics 70 people with diabetes have died of cardiovascular diseases
Framingham s study has proven the increase of the congestive heart-failure 241 in male patients and51 in female patients which has no association with the age hypertension obesity cardiovascular disease and Hyperlipidemia1 Other prospective studies also showed that the patients with diabetes in the early stage may be subject to abnormal echocardiogram and their probabilities of suffering from heart failure in the lifetime and Q-wave and non-Q wave myocardial infarction will be increased12 Early in 2000 American Heart Association issued a statement that diabetes is a cardiovascular disease 3and in 2007 with reference to the joint guidelines concerning diabetes pre-diabetes and cardiovascular disease European Society of Cardiology ESC and the European Diabetes Research Institute ESAD clearly pointed out that hyperglycemia and cardiovascular disease CVD are closely related and the danger of CVD can be raised notably for those whose blood glucose is normal when fasting but tend to increase postprandially4 In the pathogenesis study of cardiovascular complications of diabetes the promotion of oxidative stress and declination of the heart antioxidant reserves have close associations with the cardiovascular complications in animal and human body5 A number of cytokines and inflammatory signaling pathways are involved including tumor necrosis factor-α TNF-α high-sensitivity C-reactive protein HsCRP adiponectin IL-6 NF-κB16 Accordingly this study analyzes the echocardiography high-sensitivity C-reactive protein and tumor necrosis factor-α of the patients with diabetics in our hospital in order to find early warning indicators of the cardiovascular complications of diabetes and provide prevention and treatment for cardiovascular complications of diabetes
Framingham s study has proven the increase of the congestive heart-failure 241 in male patients and51 in female patients which has no association with the age hypertension obesity cardiovascular disease and Hyperlipidemia1 Other prospective studies also showed that the patients with diabetes in the early stage may be subject to abnormal echocardiogram and their probabilities of suffering from heart failure in the lifetime and Q-wave and non-Q wave myocardial infarction will be increased12 Early in 2000 American Heart Association issued a statement that diabetes is a cardiovascular disease 3and in 2007 with reference to the joint guidelines concerning diabetes pre-diabetes and cardiovascular disease European Society of Cardiology ESC and the European Diabetes Research Institute ESAD clearly pointed out that hyperglycemia and cardiovascular disease CVD are closely related and the danger of CVD can be raised notably for those whose blood glucose is normal when fasting but tend to increase postprandially4 In the pathogenesis study of cardiovascular complications of diabetes the promotion of oxidative stress and declination of the heart antioxidant reserves have close associations with the cardiovascular complications in animal and human body5 A number of cytokines and inflammatory signaling pathways are involved including tumor necrosis factor-α TNF-α high-sensitivity C-reactive protein HsCRP adiponectin IL-6 NF-κB16 Accordingly this study analyzes the echocardiography high-sensitivity C-reactive protein and tumor necrosis factor-α of the patients with diabetics in our hospital in order to find early warning indicators of the cardiovascular complications of diabetes and provide prevention and treatment for cardiovascular complications of diabetes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| Endocrine Department | None | None | None |