Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00035737
Status:
COMPLETED
Last Update Posted:
2014-02-21
First Post:
2002-05-04
Brief Title:
Vascular Function in the Framingham Third Generation
Sponsor:
Boston University
Organization:
Boston University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2014-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the role of endothelial dysfunction and increased vascular stiffness as contributors to the pathogenesis of cardiovascular disease
Detailed Description:
BACKGROUND
Increasingly researchers understand that endothelial dysfunction and increased vascular stiffness contribute to the pathogenesis of cardiovascular disease CVD The Framingham Heart Study FHS has been examining vascular function in about 3600 middle-aged and elderly participants of the FHS Offspring and minority OMNI cohorts
DESIGN NARRATIVE
The study characterizes vascular function by performing noninvasive studies of endothelial function with brachial ultrasound flow-mediated dilation and of vascular stiffness with arterial tonometry in 3850 adult offspring of the FHS Offspring and OMNI cohorts The total of over 7000 vascular examinations in an extensively studied multi-generational community-based cohort provides the opportunity to characterize the environmental and genetic determinants and the prognosis of altered vascular function The study hypotheses are vascular function is determined by both environmental and genetic factors endothelial function and vascular stiffness phenotypes are associated with each other and vascular dysfunction predisposes to the development of hypertension HTN and cardiovascular disease
Increasingly researchers understand that endothelial dysfunction and increased vascular stiffness contribute to the pathogenesis of cardiovascular disease CVD The Framingham Heart Study FHS has been examining vascular function in about 3600 middle-aged and elderly participants of the FHS Offspring and minority OMNI cohorts
DESIGN NARRATIVE
The study characterizes vascular function by performing noninvasive studies of endothelial function with brachial ultrasound flow-mediated dilation and of vascular stiffness with arterial tonometry in 3850 adult offspring of the FHS Offspring and OMNI cohorts The total of over 7000 vascular examinations in an extensively studied multi-generational community-based cohort provides the opportunity to characterize the environmental and genetic determinants and the prognosis of altered vascular function The study hypotheses are vascular function is determined by both environmental and genetic factors endothelial function and vascular stiffness phenotypes are associated with each other and vascular dysfunction predisposes to the development of hypertension HTN and cardiovascular disease
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL070100 | NIH | None | httpsreporternihgovquickSearchR01HL070100 |