Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:03 AM
Study NCT ID:
NCT00002725
Status:
COMPLETED
Last Update Posted:
2013-02-05
First Post:
1999-11-01
Brief Title:
Bryostatin-1 in Treating Patients With Recurrent Non-Hodgkins Lymphoma
Sponsor:
National Cancer Institute NCI
Organization:
National Cancer Institute NCI
Study Overview
Official Title:
PHASE II EVALUATION OF BRYOSTATIN-1 NSC 339555 IN NON-HODGKINS LYMPHOMA
Status:
COMPLETED
Status Verified Date:
2000-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Phase II trial to study the effectiveness of bryostatin-1 in treating patients with recurrent non-Hodgkins lymphoma Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die
Detailed Description:
OBJECTIVES
I Determine the response to bryostatin 1 BRYO administered weekly for 3 weeks in patients with relapsed non-Hodgkins lymphoma
II Assess the toxic effects of this treatment III Establish the correlation between PKC isoenzyme activity and BRYO function in lymphoma cells and normal lymphocytes
IV Determine the pharmacokinetic profile of BRYO and its relationship to pharmacodynamics
OUTLINE
Single-Agent ChemotherapyDifferentiation Therapy Bryostatin 1 BRYO NSC-339555
I Determine the response to bryostatin 1 BRYO administered weekly for 3 weeks in patients with relapsed non-Hodgkins lymphoma
II Assess the toxic effects of this treatment III Establish the correlation between PKC isoenzyme activity and BRYO function in lymphoma cells and normal lymphocytes
IV Determine the pharmacokinetic profile of BRYO and its relationship to pharmacodynamics
OUTLINE
Single-Agent ChemotherapyDifferentiation Therapy Bryostatin 1 BRYO NSC-339555
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| MDA-DM-95061 | None | None | None |
| NCI-T95-0035D | None | None | None |
| CDR0000064591 | REGISTRY | PDQ Physician Data Query | None |