Ignite Creation Date:
2024-05-05 @ 9:40 PM
Last Modification Date:
2024-10-26 @ 10:07 AM
Study NCT ID:
NCT00936416
Status:
COMPLETED
Last Update Posted:
2012-01-18
First Post:
2009-07-08
Brief Title:
Assessment of Renal Physiology by Magnetic Resonance Imaging MRI in Normal Volunteers
Sponsor:
University Health Network Toronto
Organization:
University Health Network Toronto
Study Overview
Official Title:
Assessment of Renal Physiology Glomerular Filtration Rate and Blood Flow by MRI With Validation by Inulin and Para-Aminohippuric Acid Clearance in Normal Volunteers
Status:
COMPLETED
Status Verified Date:
2012-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Estimation of Glomerular Filtration Rate GFR is the primary test used to assess patients with renal disease Although serum creatinine based GFR and nuclear medicine based estimations are routinely used in clinical practice GFR estimation by Inulin is the recommended gold standard Inulin based estimation of GFR is cumbersome and time consuming
A decrease in blood flow to the kidney Renal Blood Flow RBF is known to cause a decrease in GFR RBF is typically determined using radioactive tracers contrast MRI or a cumbersome para-aminohippuric acid PAH clearance method
MRI based assessment of GFR and RBF have been suggested to provide reasonable accuracy Most of these studies did not compare the GFR and RBF estimation directly to Inulin and PAH clearance which are ther gold standards In this study we propose to estimate MRI based GFR estimation directly to Inulin and noncontrast MRI based derived RBF to PAH to assess if MRI is an accurate test of kidney function
A decrease in blood flow to the kidney Renal Blood Flow RBF is known to cause a decrease in GFR RBF is typically determined using radioactive tracers contrast MRI or a cumbersome para-aminohippuric acid PAH clearance method
MRI based assessment of GFR and RBF have been suggested to provide reasonable accuracy Most of these studies did not compare the GFR and RBF estimation directly to Inulin and PAH clearance which are ther gold standards In this study we propose to estimate MRI based GFR estimation directly to Inulin and noncontrast MRI based derived RBF to PAH to assess if MRI is an accurate test of kidney function
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None