Ignite Creation Date:
2024-05-05 @ 9:39 PM
Last Modification Date:
2024-10-26 @ 10:07 AM
Study NCT ID:
NCT00936234
Status:
WITHDRAWN
Last Update Posted:
2020-09-02
First Post:
2009-07-08
Brief Title:
Functional Improvement of Progenitor Cells and Endothelial Function by Vildagliptin in Diabetes Mellitus FINNjA-DM
Sponsor:
Johann Wolfgang Goethe University Hospital
Organization:
Johann Wolfgang Goethe University Hospital
Study Overview
Official Title:
Functional Improvement of Progenitor Cells and Endothelial Function by Vildagliptin in Diabetes Mellitus FINNjA-DM
Status:
WITHDRAWN
Status Verified Date:
2020-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
insufficient recruitment
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FINNjA-DM
Brief Summary:
SDF-1 an important cytokine for neovascularisation is cleaved by dipeptidyl peptidase IV DPPIV
The aim of this study is to assess the effect of the dipeptidyl peptidase IV inhibitor vildagliptin Galvus on endothelial function as well as number and functional activity of progenitor cells in patients with documented diabetes mellitus
The aim of this study is to assess the effect of the dipeptidyl peptidase IV inhibitor vildagliptin Galvus on endothelial function as well as number and functional activity of progenitor cells in patients with documented diabetes mellitus
Detailed Description:
The peptidase CD26 DPPIVdipeptidyl peptidase IV removes dipeptides from the amino terminus of proteins and thereby inactivates these cleaved proteins It was shown that CD26 cleaves SDF-1 into a non-mitogenic molecule Inhibition or deletion of CD26 leads to an increased homing of hematopoietic progenitor cells to the bone marrow after transplantation by increasing the invasion capacity of these cells Campbell et al 2008 Christopherson et al 2004
The cytokine SDF-1 is released in response to hypoxia is crucial for progenitor cell homing and recruitment of cells for neovascularisation Invasion capacity is closely related to the cytokine SDF-1 and the SDF-1 receptor CXCR4 Ceradini et al 2004 The in vivo neovascularisation capacity of progenitor cells is closely correlated to their functional capacity as SDF-1 induced invasion or colony-forming capacity Heeschen et al 2004 Britten et al 2003 Assmus et al 2007
Therefore the aim of this study is to assess the effect of the dipeptidyl peptidase IV inhibitor vildagliptin on endothelial function as well as number and functional activity of progenitor cells in patients with documented diabetes mellitus
The cytokine SDF-1 is released in response to hypoxia is crucial for progenitor cell homing and recruitment of cells for neovascularisation Invasion capacity is closely related to the cytokine SDF-1 and the SDF-1 receptor CXCR4 Ceradini et al 2004 The in vivo neovascularisation capacity of progenitor cells is closely correlated to their functional capacity as SDF-1 induced invasion or colony-forming capacity Heeschen et al 2004 Britten et al 2003 Assmus et al 2007
Therefore the aim of this study is to assess the effect of the dipeptidyl peptidase IV inhibitor vildagliptin on endothelial function as well as number and functional activity of progenitor cells in patients with documented diabetes mellitus
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None