Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00037271
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2002-05-16
Brief Title:
Genome Scan for Obesity in a Multi-Ethnic Sample
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To scan the genome for obesity in a multi-ethnic sample
Detailed Description:
BACKGROUND
Despite intensive efforts the genetic basis of obesity has been difficult to establish Linkage analysis using a genome-wide scan can potentially identify genomic regions not previously thought to be associated with susceptibility to obesity and provides a comprehensive test of the consistency of previous studies The study used the considerable resources generated by the four cooperating networks in the NHLBI-supported Family Blood Pressure Program FBPP to conduct a genome-wide scan data for obesity
DESIGN NARRATIVE
In the Family Blood Pressure Program microsatellite markers were typed at a density of -10cM by the Mammalian Genotyping Service MGS in Marshfield WI The complete data set was to include 9940 individuals representing 4 ethnic groups white black Hispanic and Asian Obesity was characterized as a weightheight ratio body mass index and waisthip ratio This data set was larger than any prior genome scan for obesity and the inclusion of multiple ethnic groups made it possible to examine genetic heterogeneity The specific aims of the study were to conduct linkage and association analyses to localize regions influencing obesity Investigators worked closely with the FBPP Coordinating Center Washington University St Louis and investigators from each of the four FBPP networks Evidence was sought for consistency between results obtained from analyses of the genome scan performed by each of the individuals and results summarized from the literature with those found in meta-analysis
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Despite intensive efforts the genetic basis of obesity has been difficult to establish Linkage analysis using a genome-wide scan can potentially identify genomic regions not previously thought to be associated with susceptibility to obesity and provides a comprehensive test of the consistency of previous studies The study used the considerable resources generated by the four cooperating networks in the NHLBI-supported Family Blood Pressure Program FBPP to conduct a genome-wide scan data for obesity
DESIGN NARRATIVE
In the Family Blood Pressure Program microsatellite markers were typed at a density of -10cM by the Mammalian Genotyping Service MGS in Marshfield WI The complete data set was to include 9940 individuals representing 4 ethnic groups white black Hispanic and Asian Obesity was characterized as a weightheight ratio body mass index and waisthip ratio This data set was larger than any prior genome scan for obesity and the inclusion of multiple ethnic groups made it possible to examine genetic heterogeneity The specific aims of the study were to conduct linkage and association analyses to localize regions influencing obesity Investigators worked closely with the FBPP Coordinating Center Washington University St Louis and investigators from each of the four FBPP networks Evidence was sought for consistency between results obtained from analyses of the genome scan performed by each of the individuals and results summarized from the literature with those found in meta-analysis
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R03HL065702 | NIH | None | httpsreporternihgovquickSearchR03HL065702 |