Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00034723
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2002-05-01
Brief Title:
MRI Brain Studies in Patients With HTLV-1 Associated MyelopathyTropical Spastic Paraparesis
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
MRI Investigation Of The CNS In HTLV-1 Associated MyelopathyTropical Spastic Paraparesis HAMTSP
Status:
COMPLETED
Status Verified Date:
2004-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use three different magnetic resonance imaging MRI techniques to study HTLV-1 associated myelopathytropical spastic paraparesis HAMSTP-a disease of slowly progressive weakness in the legs It is not known how the HTLV-1 virus causes this disease but it is thought that as the bodys immune system tries to destroy the virus parts of the nervous system-primarily the spinal cord-are damaged
Patients 18 years of age and older with HAMTSP and healthy normal volunteers may be eligible for this study
Participants will undergo diffusion tensor MRI MR-spectroscopy and magnetization transfer imaging to look at different compositional architectural and microscopic properties of the brain All of these techniques are similar to conventional MRI and like the conventional method they use a strong magnetic field and radio waves to measure structural and chemical changes in brain tissue Each of the three scans will be done on separate days each lasting about 1 hour For the procedures the patient or volunteer lies on a stretcher in a narrow metal cylinder the scanner and is asked to remain still for 15 to 30 minutes at a time A special lightweight coil may be placed on the head to enhance the brain images The subject can communicate with the person doing the scan at all times
Patients 18 years of age and older with HAMTSP and healthy normal volunteers may be eligible for this study
Participants will undergo diffusion tensor MRI MR-spectroscopy and magnetization transfer imaging to look at different compositional architectural and microscopic properties of the brain All of these techniques are similar to conventional MRI and like the conventional method they use a strong magnetic field and radio waves to measure structural and chemical changes in brain tissue Each of the three scans will be done on separate days each lasting about 1 hour For the procedures the patient or volunteer lies on a stretcher in a narrow metal cylinder the scanner and is asked to remain still for 15 to 30 minutes at a time A special lightweight coil may be placed on the head to enhance the brain images The subject can communicate with the person doing the scan at all times
Detailed Description:
Magnetic Resonance Imaging MRI has become an important tool in the diagnosis of inflammatory CNS diseases such as Multiple Sclerosis MS and HTLV-1 Associated MyelopathyTropical Spastic Paraparesis HAM-TSP It is widely used as a marker for disease activity and progression However conventional MRI methods are only suitable to study gross anatomical features such as size and shape of a particular area of the brain questions regarding intrinsic microstructure and morphologic specificity cannot be addressed But axonal damage or structural abnormalities even in normal appearing brain tissue may play an important role in the development of irreversible disability Magnetization Transfer Imaging Magnetic Resonance Spectroscopy and Diffusion Tensor MRI are imaging techniques described to be capable of the detection of such changes Spectroscopy can detect molecular components in tissue whereas the Magnetization Transfer Ratio MTR allows the measurement of water-macromolecule interactions Diffusion Tensor MRI DT-MRI is an imaging modality that combines features of in vivo anatomical MRI and histopathology it is an in vivo MRI method that provides information about tissue composition microstructure organization and architecture This is possible because water diffusion properties in tissues as measured by DT-MRI are affected by tissue constituents such as macromolecules membranes organelles as well as by tissue microstructure architecture and organization A study comprising Magnetization Transfer- Spectroscopy- and DT-MRI furnishes important information that cannot be obtained using conventional MRI methods
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0180 | None | None | None |