Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00037908
Status:
COMPLETED
Last Update Posted:
2009-01-21
First Post:
2002-05-24
Brief Title:
Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis
Status:
COMPLETED
Status Verified Date:
2002-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Our overall goal is to develop therapeutic interventions to improve upper-limb motor function in hemiparetic persons based on an improved understanding of the mechanisms responsible for its loss and recovery We intend to rigorously evaluate the efficacy of these interventions with clinical trials and to study the mechanisms by which these interventions affect motor recovery In this proposal we will use a controlled randomized double blind clinical trial to study the effects of shoulder and elbow strength training in subjects in the subacute phase of recovery following stroke
Detailed Description:
Hypotheses The specific hypotheses that we will test in this proposal all refer to persons with post-stroke hemiparesis in the subacute phase of recovery completed all out-patient therapy programs but still less than 6 months post-CVA
1 a Standard functional rehabilitation combined with strength training in the form of high-intensity resistance exercise results in greater gains in elbow and shoulder strength than standard functional rehabilitation alone
b This increased strength is not accompanied by increased hypertonia c This increased strength is not accompanied by significant muscular hypertrophy
2 Standard functional rehabilitation combined with strength training results in greater improvements in motor function than functional rehabilitation alone
3 Strength training results in improved control of elbow trajectory tracking movements and shoulder-elbow reaching movements
Specific Objectives
1 To perform a controlled randomized double-blind clinical trial to test the effects of high-intensity resistance exercise at the shoulder and elbow Two interventions will be compared standard functional rehabilitation SFR and standard functional rehabilitation combined with high-intensity resistance exercise strength training SFRSTR We will study persons with post-stroke hemiparesis in the subacute phase of recovery ie having completed all outpatient therapy programs but still less than 6 months post-CVA Outcome measures will include strength maximal voluntary isovelocity joint torque hypertonia onset threshold of the stretch reflex Modified Ashworth Scale standard clinical assessment of activities of daily living Barthel Index Functional Independence Measure and upper extremity motor function Fugl-Meyer exam Functional Test of the Hemiparetic Upper Extremity
2 To study the neuromuscular mechanisms associated with improvements in strength and motor control that result from these interventions Strength changes will be investigated by measuring muscle hypertrophy hyperreflexia and passive stiffness Changes in control of upper extremity movements will be investigated by measuring motor performance and muscle activation patterns in trajectory tracking and reaching tasks
Our long term goal is to develop therapeutic interventions to improve upper-limb motor function in persons with post-stroke hemiparesis Improved motor function involves not only increased strength at the shoulder and elbow but also increased strength and dexterity at the wrist and hand The proposed study will establish a foundation by demonstrating the positive effects of strength training in persons with hemiparesis Then in future studies we can investigate the effects of specific interventions at the hand and wrist and investigate physiologic mechanisms subserving change in neuromuscular function following strength training
1 a Standard functional rehabilitation combined with strength training in the form of high-intensity resistance exercise results in greater gains in elbow and shoulder strength than standard functional rehabilitation alone
b This increased strength is not accompanied by increased hypertonia c This increased strength is not accompanied by significant muscular hypertrophy
2 Standard functional rehabilitation combined with strength training results in greater improvements in motor function than functional rehabilitation alone
3 Strength training results in improved control of elbow trajectory tracking movements and shoulder-elbow reaching movements
Specific Objectives
1 To perform a controlled randomized double-blind clinical trial to test the effects of high-intensity resistance exercise at the shoulder and elbow Two interventions will be compared standard functional rehabilitation SFR and standard functional rehabilitation combined with high-intensity resistance exercise strength training SFRSTR We will study persons with post-stroke hemiparesis in the subacute phase of recovery ie having completed all outpatient therapy programs but still less than 6 months post-CVA Outcome measures will include strength maximal voluntary isovelocity joint torque hypertonia onset threshold of the stretch reflex Modified Ashworth Scale standard clinical assessment of activities of daily living Barthel Index Functional Independence Measure and upper extremity motor function Fugl-Meyer exam Functional Test of the Hemiparetic Upper Extremity
2 To study the neuromuscular mechanisms associated with improvements in strength and motor control that result from these interventions Strength changes will be investigated by measuring muscle hypertrophy hyperreflexia and passive stiffness Changes in control of upper extremity movements will be investigated by measuring motor performance and muscle activation patterns in trajectory tracking and reaching tasks
Our long term goal is to develop therapeutic interventions to improve upper-limb motor function in persons with post-stroke hemiparesis Improved motor function involves not only increased strength at the shoulder and elbow but also increased strength and dexterity at the wrist and hand The proposed study will establish a foundation by demonstrating the positive effects of strength training in persons with hemiparesis Then in future studies we can investigate the effects of specific interventions at the hand and wrist and investigate physiologic mechanisms subserving change in neuromuscular function following strength training
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None