Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00032422
Status:
COMPLETED
Last Update Posted:
2006-08-18
First Post:
2002-03-20
Brief Title:
Acupuncture in Cardiovascular Disease
Sponsor:
National Center for Complementary and Integrative Health NCCIH
Organization:
National Center for Complementary and Integrative Health NCCIH
Study Overview
Official Title:
Acupuncture in Cardiovascular Disease
Status:
COMPLETED
Status Verified Date:
2006-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine if acupuncture decreases adrenaline levels in heart failure thereby potentially improving survival and quality of life
Detailed Description:
Acupuncture is used to lower blood pressure in patients with hypertension and to relieve angina in patients with coronary artery disease While the biological mechanisms of acupuncture analgesia have been studied intensely in animals and humans the biological mechanisms for modulation of the cardiovascular system in humans remain largely unexplored Acupuncture at traditional acupoints and at nonacupoints decreases the blood pressure response during mental stress in normal humans This depressor effect cannot be fully explained by a decline in muscle sympathetic nerve activity MSNA Further in humans with heart failure HF in whom MSNA is elevated we have preliminary data that acupuncture significantly decreases the MSNA response during mental stress The following hypotheses will be tested 1 acupuncture performed at traditional acupoints and non-acupoints in normal humans stimulates skeletal muscle afferent neurons causing a release of endogenous opioids which oppose sympathetic excitation and vasoconstriction in visceral vascular beds such as the kidney 2 in humans with HF in whom MSNA is elevated and renal vasoconstriction is the rule acupuncture utilizes similar mechanisms as in normal humans to produce exaggerated inhibition of MSNA and reflex renal vasoconstriction Positron emission tomography and microneurography will be utilized to answer the following questions in normal humans and patients with heart failure 1 Is acupuncture attenuation of BP during mental stress mediated by a decrease in renal vasoconstriction 2 Is acupuncture sympathoinhibitory 3 Is acupuncture modulation of the autonomic nervous system mediated by muscle afferents 4 Is acupuncture modulation of the autonomic nervous system mediated by activation of endogenous opioids Understanding the mechanisms of acupuncture modulation of the autonomic nervous system in humans may help clarify its role as a therapeutic modality in cardiovascular diseases such as heart failure
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None