Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00037505
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
2002-05-17
Brief Title:
Major Depression and Inflammatory Risk Markers for Coronary Heart Disease
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
Major Depression and Inflammatory Risk Markers for Coronary Heart Disease
Status:
COMPLETED
Status Verified Date:
2003-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall purpose of this research is to examine whether depression influences immune system function Studies indicate that individuals who are depressed experience coronary heart disease at a higher rate than expected This studys goal is to begin identifying mechanisms that might be responsible for this process This research also examines whether behavioral processes eg smoking or hormonal processes eg adrenaline release are responsible for immune system differences between depressed and nondepressed people
Detailed Description:
To qualify for participation subjects are to be between the ages of 18-55 medically healthy and free of all medication three months prior to enrollment Half of them will be clinically depressed the remaining one half will be healthy controls without a history of psychiatric illness All subjects who qualify for the study will attend two laboratory sessions During the first visit participants will undergo a structured psychological interview complete questionnaires about their mood personality and behavior and have blood drawn to assess their immune system function During the second visit participants will complete additional questionnaires about their mood personality and behavior The subjects will also participate in a mock job interview to look at their bodys response to stress Before and after the interview the subjects will have blood drawn and be asked to collect saliva samples to assess their immune system function In addition to the two laboratory visits participants will be asked to collect additional information while going about their normal activities In order to accomplish this they will be given a small hand held portable computer Four times each day for four days the computer will signal them to collect a saliva sample This will be used later to measure hormone levels This study will explore changes in the immune system and metabolic system that might predispose depressed individuals to develop heart disease
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: