Ignite Creation Date:
2025-12-24 @ 11:10 PM
Ignite Modification Date:
2025-12-25 @ 8:44 PM
Study NCT ID:
NCT03520569
Status:
COMPLETED
Last Update Posted:
2022-05-13
First Post:
2018-03-08
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults
Sponsor:
University of Virginia
Organization:
Study Overview
Official Title:
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults
Status:
COMPLETED
Status Verified Date:
2022-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EJB050
Brief Summary:
The investigators are studying the effects of Hyperglycemia on vascular function and insulin sensitivity on healthy adults
Detailed Description:
The investigators will study 22 healthy subjects (18-35 yrs) four times as follows:
1. Saline + Octreotide + euglycemia;
2. Octreotide + hyperglycemia;
3. Octreotide + hyperglycemia + insulin clamp and
4. Octreotide + Euglycemia + insulin clamp.
The sequence of admissions will be assigned randomly. The investigators will assess function in conduit (pulse wave velocity-PWV, augmentation index-AI and flow-mediated dilation-FMD), resistance (post-ischemic flow velocity-PIFV) and heart and skeletal muscle microvascular (contrast enhanced ultrasound-CEU) vessels.
This work will:
a) identify whether vascular stiffness and indices of NO action are impaired throughout the arterial tree with hyperglycemia.
1. Saline + Octreotide + euglycemia;
2. Octreotide + hyperglycemia;
3. Octreotide + hyperglycemia + insulin clamp and
4. Octreotide + Euglycemia + insulin clamp.
The sequence of admissions will be assigned randomly. The investigators will assess function in conduit (pulse wave velocity-PWV, augmentation index-AI and flow-mediated dilation-FMD), resistance (post-ischemic flow velocity-PIFV) and heart and skeletal muscle microvascular (contrast enhanced ultrasound-CEU) vessels.
This work will:
a) identify whether vascular stiffness and indices of NO action are impaired throughout the arterial tree with hyperglycemia.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| T32DK007646 | NIH | None | https://reporter.nih.gov/quic… | View |