Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00037739
Status:
COMPLETED
Last Update Posted:
2016-01-21
First Post:
2002-05-20
Brief Title:
Chronic Obstructive Pulmonary Disease Gene Localization
Sponsor:
University of Utah
Organization:
University of Utah
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To localize within the genome a chronic obstructive pulmonary disease susceptibility gene
Detailed Description:
BACKGROUND
Chronic obstructive pulmonary disease COPD is a slowly progressive disorder characterized by airways obstruction that lasts for at least several months The two major causes of COPD are chronic bronchitis and emphysema Either disorder may occur with or without airways obstruction but airways obstruction causes impairment of lung function leading to disability and death COPD is a major health problem in the United States and throughout the world consistently ranking among the most common causes of death in the United States Cigarette smoking is the primary environmental factor that increases the risk of COPD but other environmental factors have also been implicated However despite a well-established role environmental factors alone do not cause COPD Symptomatic COPD develops in only 10-20 percent of heavy cigarette smokers probably those with a genetic susceptibility although common COPD susceptibility genes have yet to be identified
DESIGN NARRATIVE
The study applied statistical linkage analysis to family data Pulmonary measurements had already been collected on 159 members of 16 pedigrees and evidence supporting a COPD susceptibility gene in these pedigrees had been obtained from segregation analysis Each of 11995 genetic markers which had already been genotyped on pedigree members were tested for evidence of linkage to the inferred COPD susceptibility gene Evidence of linkage to one or more genetic markers identifed genomic locations of COPD susceptibility genes The high density of markers allowed fine-mapping of the gene Successful completion of this gene localization project was the necessary prerequisite for a project to identify and characterize a COPD susceptibility gene Identifying a gene that when mutated increased the risk of COPD may increase understanding of pulmonary function as well as allowing gene-carriers to be identified and made aware of their susceptibility
Chronic obstructive pulmonary disease COPD is a slowly progressive disorder characterized by airways obstruction that lasts for at least several months The two major causes of COPD are chronic bronchitis and emphysema Either disorder may occur with or without airways obstruction but airways obstruction causes impairment of lung function leading to disability and death COPD is a major health problem in the United States and throughout the world consistently ranking among the most common causes of death in the United States Cigarette smoking is the primary environmental factor that increases the risk of COPD but other environmental factors have also been implicated However despite a well-established role environmental factors alone do not cause COPD Symptomatic COPD develops in only 10-20 percent of heavy cigarette smokers probably those with a genetic susceptibility although common COPD susceptibility genes have yet to be identified
DESIGN NARRATIVE
The study applied statistical linkage analysis to family data Pulmonary measurements had already been collected on 159 members of 16 pedigrees and evidence supporting a COPD susceptibility gene in these pedigrees had been obtained from segregation analysis Each of 11995 genetic markers which had already been genotyped on pedigree members were tested for evidence of linkage to the inferred COPD susceptibility gene Evidence of linkage to one or more genetic markers identifed genomic locations of COPD susceptibility genes The high density of markers allowed fine-mapping of the gene Successful completion of this gene localization project was the necessary prerequisite for a project to identify and characterize a COPD susceptibility gene Identifying a gene that when mutated increased the risk of COPD may increase understanding of pulmonary function as well as allowing gene-carriers to be identified and made aware of their susceptibility
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL067469 | NIH | None | httpsreporternihgovquickSearchR01HL067469 |