Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00032812
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2002-04-03
Brief Title:
The Role of Dopamine in Motor Learning in Healthy Subjects and Patients With Parkinsons Disease
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Motor Memory Study of the Role of Dopamine in Healthy Subjects and Patients With Parkinsons Disease Using PET and EEG
Status:
COMPLETED
Status Verified Date:
2004-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine and compare what happens in the brains of patients with Parkinsons disease with that of healthy normal subjects while they train to react as fast as possible to the appearance of a visual signal Particularly we will measure the amount of the chemical dopamine released in the brain as well as the electrical activity during training Indeed patients with Parkinsons disease frequently complain of slowness and early fatigue during movements These symptoms are believed to be related to a decrease of dopamine in the brain which may be associated with abnormalities in cerebral electrical activity
Adult patients with Parkinsons disease who are right-handed do not have dementia and are not depressed may be eligible for this study Healthy volunteers who match patients in age gender handedness and level of education will also be studied Candidates will be screened with a medical history physical and neurological examinations memory test mood evaluation and urine toxicology
All participants will be required to stop taking any medications that can influence the central nervous system and to abstain from alcohol consumption for 1 week before the screening examination and during the study training period Patients with Parkinsons disease will also be required to stop using antiparkinsonian medications for at least 12 hours before the first visit and each training session
Participants will have several 1-hour training sessions During these sessions they will sit facing a computer screen at a distance of about 32 inches 80 centimeters from their eyes Six permanent position markers will be displayed A keyboard with six spatially compatible response keys will be within reach of their right hand Participants will respond as quickly and as accurately as possible to the appearance of a stimulus eg white circle below one of the markers by pressing the spatially corresponding key About a second later the next stimulus will be displayed below one of the other markers and so on Reaction times and accuracy will be recorded After 3 to 10 minutes of practice one block there will be a rest period during which the computer will display information about the subjects accuracy of movements and reaction time Then a new block will start There will be about 6 to 20 practice blocks per training session The number of training session will vary between 3 and 6 depending on accuracy and reaction time during the task
During each training session subjects will have encephalographic EEG recordings to measure the electrical activity of the brain In addition they will have one or two positron emission tomography PET scans during the first training session and some will also have one or two PET scans during the last session For the PET scan the subject will be injected with a substance called raclopride which is taken up by the brain The raclopride is tagged with a radioactive substance so that it can be detected by the PET camera The amount of raclopride detected in the brain will provide an indirect measure of the amount of dopamine released during training
Before or after one of the training sessions participants will undergo magnetic resonance imaging MRI to study brain anatomy MRI uses a strong magnetic field and radio waves to produce images of the brain The subject lies on a table in a space enclosed by a metal cylinder the scanner The test takes about 45 to 60 minutes during which the participant must lie very still for 10 to 15 minutes at a time
Adult patients with Parkinsons disease who are right-handed do not have dementia and are not depressed may be eligible for this study Healthy volunteers who match patients in age gender handedness and level of education will also be studied Candidates will be screened with a medical history physical and neurological examinations memory test mood evaluation and urine toxicology
All participants will be required to stop taking any medications that can influence the central nervous system and to abstain from alcohol consumption for 1 week before the screening examination and during the study training period Patients with Parkinsons disease will also be required to stop using antiparkinsonian medications for at least 12 hours before the first visit and each training session
Participants will have several 1-hour training sessions During these sessions they will sit facing a computer screen at a distance of about 32 inches 80 centimeters from their eyes Six permanent position markers will be displayed A keyboard with six spatially compatible response keys will be within reach of their right hand Participants will respond as quickly and as accurately as possible to the appearance of a stimulus eg white circle below one of the markers by pressing the spatially corresponding key About a second later the next stimulus will be displayed below one of the other markers and so on Reaction times and accuracy will be recorded After 3 to 10 minutes of practice one block there will be a rest period during which the computer will display information about the subjects accuracy of movements and reaction time Then a new block will start There will be about 6 to 20 practice blocks per training session The number of training session will vary between 3 and 6 depending on accuracy and reaction time during the task
During each training session subjects will have encephalographic EEG recordings to measure the electrical activity of the brain In addition they will have one or two positron emission tomography PET scans during the first training session and some will also have one or two PET scans during the last session For the PET scan the subject will be injected with a substance called raclopride which is taken up by the brain The raclopride is tagged with a radioactive substance so that it can be detected by the PET camera The amount of raclopride detected in the brain will provide an indirect measure of the amount of dopamine released during training
Before or after one of the training sessions participants will undergo magnetic resonance imaging MRI to study brain anatomy MRI uses a strong magnetic field and radio waves to produce images of the brain The subject lies on a table in a space enclosed by a metal cylinder the scanner The test takes about 45 to 60 minutes during which the participant must lie very still for 10 to 15 minutes at a time
Detailed Description:
A dopaminergic system may play a role in some forms of motor learning At a subcortical level studies in animals and humans suggest that the striatum and its dopaminergic innervation participate in both the acquisition and retrieval of programs for sequential movements Moreover as the activity of mesencephalic dopaminergic neurons is modulated by reward predictability the nigrostriatal dopaminergic system has been proposed to participate in reinforcement of learning At a cortical level it has been suggested that in humans the dopaminergic system might modulate cortico-cortical connectivity during volitional movements The first purpose of work is to investigate the dynamic involvement of striatal dopamine DA release during different phases of implicit motor sequence learning in patients with Parkinsons disease PD compared with healthy subjects HS matched for age gender handedness and level of education Indeed PD is mainly known as a dopamine deficiency disorder-nigral projections to the motor striatum being most affected-and patients suffering from PD usually have difficulties in learning and execution of sequential motor tasks The second purpose of this study is to assess cortico-cortical connectivity during implicit motor sequence learning in both HS and PD patients Implicit motor sequence learning will be studied using a probabilistic serial reaction time SRT task in which the sequence presentation of the stimuli is based on a finite-state grammar Implicit motor sequence learning will be studied using a probabilistic serial reaction time SRT task in which the sequence presentation of the stimuli is based on a finite-state grammar Learning will be assessed by improvement in reaction time Striatal DA release will be assessed in vivo with positron emission tomography PET using a DA D2 receptor radioligand 11Craclopride Striatal 11Craclpride binding potential BP will be measured in both HS and PD under 3 main conditions at rest and during early and advanced learning phases of the SRT task At the same time we will use EEG recording to test the effect of learning the SRT task on cortico-cortical coherence in both HS and PD patients This study should provide new information on the pathphysiological role of dopamine in the formation of motor memory
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0153 | None | None | None |