Ignite Creation Date:
2024-05-05 @ 11:25 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00031382
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2002-03-02
Brief Title:
Imaging Study of Automatic Movements
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Neuroimaging Study of Automatic Movements
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study uses magnetic resonance imaging MRI to explore the brain activities involved in performing learned automatic movements Automatic movements are performed without concentrating on the details of the movement
Healthy adult volunteers are eligible for this study Candidates will have a medical history and brief physical examination and will fill out a questionnaire Women of childbearing potential will have a urine pregnancy test Pregnant women will not be enrolled
Participants will perform certain tasks involving movement of the right or left hand while undergoing MRI scanning They will undergo scanning twice-before and after practicing the movement tasks Before the second scan participants will practice the following tasks for 1 week
Tapping task - subjects use their left index finger to tap a button at a certain frequency
Sequential movement task - subjects perform sequential finger-tapping movements with their right hand in which they tap buttons with their fingers at a certain frequency in a 25-second period There are two sequences of different lengths referred to as sequence-4 and sequence-12 based on the number of movements in each unit of the sequence
Visual distraction task - 14-letter sequences consisting of the letters A G L and O will be presented and subjects will be asked to identify the number of times they see a target letter
Dual tasks - after completing all the above tasks subjects perform the following dual tasks
Tapping and visual task
Sequence-4 finger tap and visual task
Sequence-12 finger tap and visual task
Tapping and sequence-4 finger tap
Tapping and sequence-12 finger tap
When the participants can perform the dual tasks correctly 90 percent of the time the movements will be considered automatic and the subjects will undergo MRI scanning MRI uses a magnetic field and radio waves to produce images of the brain For the procedure the subject lies still on a stretcher that is moved into the scanner a narrow cylinder containing the magnet Earplugs are worn to muffle loud noises caused by electrical switching of radio frequency circuits used in the scanning process The scan will last about 15 hours
Healthy adult volunteers are eligible for this study Candidates will have a medical history and brief physical examination and will fill out a questionnaire Women of childbearing potential will have a urine pregnancy test Pregnant women will not be enrolled
Participants will perform certain tasks involving movement of the right or left hand while undergoing MRI scanning They will undergo scanning twice-before and after practicing the movement tasks Before the second scan participants will practice the following tasks for 1 week
Tapping task - subjects use their left index finger to tap a button at a certain frequency
Sequential movement task - subjects perform sequential finger-tapping movements with their right hand in which they tap buttons with their fingers at a certain frequency in a 25-second period There are two sequences of different lengths referred to as sequence-4 and sequence-12 based on the number of movements in each unit of the sequence
Visual distraction task - 14-letter sequences consisting of the letters A G L and O will be presented and subjects will be asked to identify the number of times they see a target letter
Dual tasks - after completing all the above tasks subjects perform the following dual tasks
Tapping and visual task
Sequence-4 finger tap and visual task
Sequence-12 finger tap and visual task
Tapping and sequence-4 finger tap
Tapping and sequence-12 finger tap
When the participants can perform the dual tasks correctly 90 percent of the time the movements will be considered automatic and the subjects will undergo MRI scanning MRI uses a magnetic field and radio waves to produce images of the brain For the procedure the subject lies still on a stretcher that is moved into the scanner a narrow cylinder containing the magnet Earplugs are worn to muffle loud noises caused by electrical switching of radio frequency circuits used in the scanning process The scan will last about 15 hours
Detailed Description:
A general characteristic of the motor system is that people can perform some learned movements automatically The underlying neural correlates of automatic movement have been investigated but are not fully understood In the present study in order to investigate the brain activities contributing to the phenomenon we use a specially designed dual task paradigm and functional magnetic resonance imaging fMRI technique Forty healthy adult subjects are asked to perform motor tasks squeezing of hand or sequential movement of fingers while listening to an auditory distraction task or to execute two different motor tasks simultaneously fMRI is obtained during their performance of these tasks By analyzing fMRI results we will explore the brain regions especially devoted to the automatic movements
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0135 | None | None | None |