Ignite Creation Date:
2024-05-05 @ 9:27 PM
Last Modification Date:
2024-10-26 @ 10:05 AM
Study NCT ID:
NCT00896389
Status:
COMPLETED
Last Update Posted:
2022-03-25
First Post:
2009-05-07
Brief Title:
Salt Loading and Thiazide Intervention Study
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
The Relationship Between Serine Threonine Kinase 39 STK39 Genotypes Salt Sensitivity Thiazide Diuretics-induced Blood Pressure Response
Status:
COMPLETED
Status Verified Date:
2022-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SALTI
Brief Summary:
The investigators of this study propose to examine the relationships between STK39 Serine Threonine Kinase 39 genotypes and responses to salt loading and to thiazide diuretics hydrochlorothiazide The investigators hypothesize that STK39 genotypes will be associated with the outcome of both interventions and can contribute to personalized care for hypertension
Detailed Description:
Although hypertension can be easily diagnosed and there are many medications available to treat hypertension this condition is poorly managed in many patients and is a leading cause of morbidity and mortality worldwide Because a newly identified hypertension susceptibility gene STK39 Serine Threonine Kinase 39 plays a central role in kidney sodium transport the investigators propose a pharmacogenetics study to examine the relationships between STK39 genotypes and blood pressure responses to salt loading and to thiazide diuretics hydrochlorothiazide In addition STK39 genotypes may also predict those hypertension patients more likely to develop thiazide-induced hyperglycemia The investigators hypothesize that STK39 genotypes of those single nucleotide polymorphisms SNPs that are associated with baseline systolic blood pressure SBP diastolic blood pressure DBP and hypertension status will be associated with the outcome of both interventions Therefore these SNPs can act as markers and contribute to personalized care for hypertension by identifying patients most likely to effectively control their blood pressure by adopting salt-reducing diet versus patients most likely to effectively and safely control their blood pressure by taking thiazide diuretics
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R21DK084566 | NIH | None | httpsreporternihgovquickSearchR21DK084566 |