Ignite Creation Date:
2024-05-05 @ 9:26 PM
Last Modification Date:
2024-10-26 @ 10:04 AM
Study NCT ID:
NCT00886457
Status:
TERMINATED
Last Update Posted:
2011-07-20
First Post:
2009-04-21
Brief Title:
5-aza-2-deoxycytidine With Pegylated Interferon-alfa 2B A Phase I Study With Molecular Correlates
Sponsor:
Nevada Cancer Institute
Organization:
Nevada Cancer Institute
Study Overview
Official Title:
Inhibition of DNA Methylation by 1-hr Infusion of 5-aza-2-Deoxycytidine Decitabine x 10 Days M-F With Escalating Doses of Sub-Q Pegylated PEG Interferon-alfa 2B PEG-Intron A Phase I Study With Molecular Correlates
Status:
TERMINATED
Status Verified Date:
2011-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
low accrual
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to assess toxicities of a 1-hr infusion of 5-aza-2-deoxycytidine decitabine x 10 days M-F plus escalating doses of weekly subcutaneous PEG-interferon-α PEG-Intron in patients with metastatic cancer and to identify the maximum tolerated dose of PEG-Intron in this combination The pre- and post-treatment samples will be evaluated to identify changes in molecular correlates
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NCI 8224 | None | None | None |