Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00029302
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2002-01-09
Brief Title:
Brain Control of Bimanual Both Hands Movements
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Brain Areas Involved in Temporal Linkage of Bilateral Movements
Status:
COMPLETED
Status Verified Date:
2008-12-24
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use magnetic resonance imaging MRI to investigate how the brain controls bimanual movements movements of both hands
Healthy normal volunteers between 21 and 65 years of age may be eligible for this study
Participants will have a medical history physical and neurological examinations and will complete a questionnaire before and after testing The study consists of two parts 1 finger movement training and 2 magnetic resonance imaging as follows
Part 1 - Finger movement training
Participants will train to do three different finger movements using the index finger of both hands The fingers will be taped to a device that measures their movement The movements are
Lifting and dropping the index fingers of each hand repetitively and in synchrony starting and stopping at the same time The amplitude of finger movements is the same for both hands
Lifting and dropping the index fingers of each hand repetitively and in synchrony but with a different amplitude for each hand
Lifting and dropping of the index finger of each hand repetitively but each with a different amplitude and not in synchrony
Part 2 - Magnetic resonance imaging
Participants will perform the trained movements during MRI scanning This diagnostic procedure uses a magnetic field and radio waves to produce images of brain structure and activity For MRI the subject lies on a stretcher that is moved into the scanner-a cylinder containing a strong magnet Earplugs are worn to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits Scanning time varies from 20 minutes to 2 hours with most examinations lasting 1 to 1 12 hours The subject can communicate with the staff person conducting the test at all times during the scan
Healthy normal volunteers between 21 and 65 years of age may be eligible for this study
Participants will have a medical history physical and neurological examinations and will complete a questionnaire before and after testing The study consists of two parts 1 finger movement training and 2 magnetic resonance imaging as follows
Part 1 - Finger movement training
Participants will train to do three different finger movements using the index finger of both hands The fingers will be taped to a device that measures their movement The movements are
Lifting and dropping the index fingers of each hand repetitively and in synchrony starting and stopping at the same time The amplitude of finger movements is the same for both hands
Lifting and dropping the index fingers of each hand repetitively and in synchrony but with a different amplitude for each hand
Lifting and dropping of the index finger of each hand repetitively but each with a different amplitude and not in synchrony
Part 2 - Magnetic resonance imaging
Participants will perform the trained movements during MRI scanning This diagnostic procedure uses a magnetic field and radio waves to produce images of brain structure and activity For MRI the subject lies on a stretcher that is moved into the scanner-a cylinder containing a strong magnet Earplugs are worn to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits Scanning time varies from 20 minutes to 2 hours with most examinations lasting 1 to 1 12 hours The subject can communicate with the staff person conducting the test at all times during the scan
Detailed Description:
OBJECTIVE The present study is aimed to clarify which structure or network of structures are responsible for the temporal linkage in bimanual co-ordination in healthy humans
STUDY POPULATION Healthy normal volunteers
DESIGN
fMRI Anatomical MRI and fMRI sequences are performed to obtain blood-oxygenation level-dependent BOLD imaging of brain activation during which movement performance will be measured with respect to movement synchrony movement speed and amplitude
Multi-channel EEG recording performed while motor performance is monitored
OUTCOME MEASURES
fMRI BOLD will be obtained using baseline correction
EEG band-power and inter-regional coherence will be calculated using baseline correction
STUDY POPULATION Healthy normal volunteers
DESIGN
fMRI Anatomical MRI and fMRI sequences are performed to obtain blood-oxygenation level-dependent BOLD imaging of brain activation during which movement performance will be measured with respect to movement synchrony movement speed and amplitude
Multi-channel EEG recording performed while motor performance is monitored
OUTCOME MEASURES
fMRI BOLD will be obtained using baseline correction
EEG band-power and inter-regional coherence will be calculated using baseline correction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0069 | None | None | None |