Ignite Creation Date:
2024-05-05 @ 9:23 PM
Last Modification Date:
2024-10-26 @ 10:03 AM
Study NCT ID:
NCT00876135
Status:
COMPLETED
Last Update Posted:
2013-05-13
First Post:
2009-04-03
Brief Title:
Role of Airway Hyperresponsiveness on Performance in Elite Swimmers
Sponsor:
Laval University
Organization:
Laval University
Study Overview
Official Title:
Role of Airway Hyperresponsiveness on Performance in Elite Swimmers Efficiency of a Bronchodilator to Prevent an Exercise-induced Bronchoconstriction
Status:
COMPLETED
Status Verified Date:
2013-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The prevalence of airway hyperresponsiveness AHR is very high in elite swimmers reaching 80 in certain studies Repeated Chlorine-derivatives exposure may be a major causative factor for its development Asthma diagnosis is generally made on the basis of clinical characteristics The demonstration of a variable bronchial obstruction through positive expiratory flow reversibility to a bronchodilator spontaneous variations of airway obstruction or a positive provocation test methacholine eucapnic voluntary hyperpnoea is necessary to avoid false diagnosis Currently asthma treatment in swimmers is the same as in the general population A short-acting bronchodilator is often prescribed to avoid occasional symptoms combined with an inhaled corticosteroid or an antagonist of Leukotriene if asthma symptoms are persistent Previous studies have shown a reduced efficiency for asthma medication in elite athletes compared with non-athletes The specific response to different medications remains to be studied in athletes The effects of a short-acting bronchodilator in swimmers with AHR especially when asymptomatic on pulmonary function and performance have not yet been studied Moreover the significance of a positive bronchial provocation test remains to be studied in asymptomatic swimmers with AHR
Detailed Description:
Our hypothesis is that swimmers with a positive bronchial provocation challenge have not necessarily an exercise-induced bronchoconstriction during swimming and the use of a bronchodilator will be unnecessary Chlorine-derivatives exposure may be responsible for a weakness of the epithelium layer but warm and humid atmosphere of the swimming-pools may be protective for the development of a bronchoconstriction Thus we also hypothesis that during a field test outside the swimming pool swimmers will develop an exercise-induced asthma and will need to take a bronchodilator in prevention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None