Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005409
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Longitudinal Studies of Blood Pressure in the Elderly
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study further the association between blood pressure mortality among those who participated in both the Hypertension Detection and Follow-up Program HDFP screen and the East Boston Established Populations for Epidemiologic Studies in the Elderly EPESE study
Detailed Description:
BACKGROUND
In middle-age level of blood pressure BP is a strong and independent predictor of both total and cardiovascular disease CVD mortality However among the elderly recent short-term observational studies including the East Boston Established Populations for Epidemiologic Studies in the Elderly EPESE have raised the possibility of a J-shaped curve In a study of short-term mortality low blood pressures were positively associated with total and cardiovascular disease mortality However a further analysis confined to the 2079 68 percent of this cohort who were also screened nine years previously for the Hypertension Detection and Follow-Up Program showed the more conventional positive linear relationship between systolic blood pressure and no association between diastolic blood pressure and mortality The observations of higher short-term total and cardiovascular disease mortality at lower blood pressure levels among the elderly could have reflected a particular susceptibility to deleterious consequences of drug therapy for high blood pressure Alternatively such a finding might have been artifactual due to survival bias or confounding by co-morbid conditions
DESIGN NARRATIVE
Linking data from the HDFP and the EPESE studies the investigators examined change in blood pressure antihypertensive medication use and mortality over a 15-year period With regard to the association between lower blood pressure and increased mortality they determined whether the relationship previously observed reflected a fall from normotensive levels as opposed to a consistently low blood pressure With regard to the upper end of the mortality curve they assessed the effect of antihypertensive drug treatment on mortality as compared to those with untreated hypertension The latter question had particular public health significance because questions remained about the risk-to-benefit ratio of antihypertensive drug treatment in this age group Furthermore they also described changes in blood pressure in this population and medication usage patterns over time and correlated type of medication and mortality
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
In middle-age level of blood pressure BP is a strong and independent predictor of both total and cardiovascular disease CVD mortality However among the elderly recent short-term observational studies including the East Boston Established Populations for Epidemiologic Studies in the Elderly EPESE have raised the possibility of a J-shaped curve In a study of short-term mortality low blood pressures were positively associated with total and cardiovascular disease mortality However a further analysis confined to the 2079 68 percent of this cohort who were also screened nine years previously for the Hypertension Detection and Follow-Up Program showed the more conventional positive linear relationship between systolic blood pressure and no association between diastolic blood pressure and mortality The observations of higher short-term total and cardiovascular disease mortality at lower blood pressure levels among the elderly could have reflected a particular susceptibility to deleterious consequences of drug therapy for high blood pressure Alternatively such a finding might have been artifactual due to survival bias or confounding by co-morbid conditions
DESIGN NARRATIVE
Linking data from the HDFP and the EPESE studies the investigators examined change in blood pressure antihypertensive medication use and mortality over a 15-year period With regard to the association between lower blood pressure and increased mortality they determined whether the relationship previously observed reflected a fall from normotensive levels as opposed to a consistently low blood pressure With regard to the upper end of the mortality curve they assessed the effect of antihypertensive drug treatment on mortality as compared to those with untreated hypertension The latter question had particular public health significance because questions remained about the risk-to-benefit ratio of antihypertensive drug treatment in this age group Furthermore they also described changes in blood pressure in this population and medication usage patterns over time and correlated type of medication and mortality
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R03HL046923 | NIH | None | httpsreporternihgovquickSearchR03HL046923 |