Ignite Creation Date:
2024-05-05 @ 9:21 PM
Last Modification Date:
2024-10-26 @ 10:03 AM
Study NCT ID:
NCT00869505
Status:
COMPLETED
Last Update Posted:
2009-03-26
First Post:
2009-03-25
Brief Title:
Study of Memantine Augmentation in Severe Obsessive-Compulsive Disorder
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
A Chart Review of Memantine Use in the Treatment of Obsessive-Compulsive Disorder at the OCD Institute
Status:
COMPLETED
Status Verified Date:
2009-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Memantine is a glutamate receptor antagonist that has been reported to reduce Obsessive-Compulsive Disorder OCD symptoms in case studies of treatment-resistant individuals The investigators hypothesized that memantine is an effective augmenting agent to standard intensive residential treatment of severe OCD An intent-to-treat single-blinded naturalistic case-control design is employed The sample includes subjects receiving standard treatment at the McLean MGH Intensive Residential Treatment IRT program half of whom also receive memantine augmentation Admission monthly and discharge measures of OCD depression and psychosocial functioning are collected by raters blinded to augmentation status Matched controls are selected based upon gender initial OCD severity psychosocial functioning and timing of admission Descriptive and comparative analyses are conducted via SPSS statistical significance is defined at p005 clinically significant response is defined by a 25 reduction and marked response is defined by a 50 improvement in Yale-Brown Obsessive Compulsive severity Y-BOCS scores using a last-observation-carried-forward approach The Clinical Global Improvement CGI scale captures global clinical change
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None