Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00028197
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-12-17
Brief Title:
Comparison of Externally and Self-Initiated Movements
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Comparison of Externally and Self-Initiated Movements
Status:
COMPLETED
Status Verified Date:
2005-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use magnetic resonance imaging MRI to investigate how the brain controls voluntary movements triggered by an external stimulus or self-initiated
Registered HCMS healthy normal volunteers may participate They will complete a questionnaire and will have a medical history and brief physical examination
The study consists of two parts 1 body movement training and 2 magnetic resonance imaging as follows
Part 1 - Body movement training
Participants will train to do three different body movements involving the hands and feet The movements will either be self-initiated or in response to a stimulus such as a visual or auditory trigger
Part 2 - Magnetic resonance imaging
Participants will do one or more of the trained movements with or without a triggering stimulus during MRI scanning MRI is a diagnostic procedure that uses a magnetic field and radio waves to produce images of brain structure and activity For the procedure the subject lies on a stretcher that is moved into the scanner-a cylinder containing a strong magnet Earplugs are worn to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits Scanning time varies from 20 minutes to 2 hours with most examinations lasting 1 to 1-12 hours The subject can communicate with the staff person conducting the test at all times during the scan A device compatible with magnetic resonance will be used to record the participants body movements The participant may be asked to push buttons of the device during the tasks
Registered HCMS healthy normal volunteers may participate They will complete a questionnaire and will have a medical history and brief physical examination
The study consists of two parts 1 body movement training and 2 magnetic resonance imaging as follows
Part 1 - Body movement training
Participants will train to do three different body movements involving the hands and feet The movements will either be self-initiated or in response to a stimulus such as a visual or auditory trigger
Part 2 - Magnetic resonance imaging
Participants will do one or more of the trained movements with or without a triggering stimulus during MRI scanning MRI is a diagnostic procedure that uses a magnetic field and radio waves to produce images of brain structure and activity For the procedure the subject lies on a stretcher that is moved into the scanner-a cylinder containing a strong magnet Earplugs are worn to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits Scanning time varies from 20 minutes to 2 hours with most examinations lasting 1 to 1-12 hours The subject can communicate with the staff person conducting the test at all times during the scan A device compatible with magnetic resonance will be used to record the participants body movements The participant may be asked to push buttons of the device during the tasks
Detailed Description:
Voluntary movements are divided into two categories one is externally triggered movement and the other is self-initiated movement The underlying neural mechanisms in each movement have been investigated but they are not fully understood The present study is aimed to understand the neural mechanisms especially aimed to find out the commonly devoted brain area for the categorized movements By obtaining functional magnetic resonance imaging fMRI signals during triggered movement tasks designed from 3 input triggers of different modalities visual auditory and somatosensory and 3 output movements of different body parts right hand left hand and right foot we will determine the brain regions specially devoted for each input or output and commonly devoted for triggered movements By obtaining fMRI signals during spontaneous voluntary movement tasks designed from 3 output movements of the same body parts we will determine the brain regions specially devoted for specific execution and commonly devoted for the voluntarily chosen movements
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0068 | None | None | None |