Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00028379
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-12-27
Brief Title:
Enhancement of Use-Dependent Plasticity by Somatosensory Stimulation in Chronic Stroke
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Enhancement of Use-Dependent Plasticity by Somatosensory Stimulation in Chronic Stroke
Status:
COMPLETED
Status Verified Date:
2005-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Recent studies have demonstrated that electrical stimulation delivered over the skin increases the muscle strength as measured by a dynamometer in chronic stroke patients We recently also found out that such stimulation enhances the ability of healthy brains to learn faster enhancing the beneficial effects of the motor training
The purpose of this study is to find out if this stimulation can enhance the ability of stroke patients to experience plastic changes in the brain It may aid in the development of new strategies for rehabilitation after brain injury in the future
A clinical and neurological exam will be administered Each patient will participate in three different sessions separated by at least 48 hours a 2-hour peripheral nerve stimulation to the weak hand a 2-hour peripheral nerve stimulation to the leg and no stimulation The sessions will be randomly ordered A magnetic resonance imaging scan of the brain will be done as well
Nerve stimulation will be done by transcranial magnetic stimulation TMS In TMS the head is immobilized within a frame An insulated coil wire is placed on the scalp and brief electrical current passed through it Participants may be asked to perform movements do simple tasks or simply tense muscles Electrical activity of the muscles will be recorded with a computer Some experiments may be recorded on videotape
Participants must be stroke patients who have recovered to the point of being able to make thumb movements and the stroke must have occurred more than 6 months ago
The purpose of this study is to find out if this stimulation can enhance the ability of stroke patients to experience plastic changes in the brain It may aid in the development of new strategies for rehabilitation after brain injury in the future
A clinical and neurological exam will be administered Each patient will participate in three different sessions separated by at least 48 hours a 2-hour peripheral nerve stimulation to the weak hand a 2-hour peripheral nerve stimulation to the leg and no stimulation The sessions will be randomly ordered A magnetic resonance imaging scan of the brain will be done as well
Nerve stimulation will be done by transcranial magnetic stimulation TMS In TMS the head is immobilized within a frame An insulated coil wire is placed on the scalp and brief electrical current passed through it Participants may be asked to perform movements do simple tasks or simply tense muscles Electrical activity of the muscles will be recorded with a computer Some experiments may be recorded on videotape
Participants must be stroke patients who have recovered to the point of being able to make thumb movements and the stroke must have occurred more than 6 months ago
Detailed Description:
There are very few therapeutic options for the treatment of motor disabilities resulting from chronic stroke Motor training results in use-dependent plasticity thought to underlie recovery of motor function after cortical lesions We recently demonstrated that stimulation of peripheral nerves SPN administered in association with motor training enhances use-dependent plasticity in healthy volunteers The purpose of this protocol is to investigate if SPN administered in association with motor training enhances use-dependent plasticity in patients with chronic stroke If so it may become an important tool to enhance the beneficial effects of rehabilitative treatment in this patient group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0082 | None | None | None |