Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00029575
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2002-01-15
Brief Title:
Magnetic Resonance Imaging of Narrowed Arteries
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Intravascular Narrow Field Magnetic Resonance Arterial Wall Imaging
Status:
COMPLETED
Status Verified Date:
2003-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will compare four methods of imaging arteries
angiography x-ray picture
intravascular ultrasound ultrasound from inside the artery
magnetic resonance imaging MRI from outside the body
MRI using an antenna to take pictures inside the arteries of the pelvis
Standard angiography shows blockages inside the artery but does not provide any information about the arterial wall itself New ways of looking at the artery walls with MRI and ultrasound may provide insight into how arteries cause disease
Patients 21 years of age and older who require catheterization and angiography of the heart kidney or leg arteries because of atherosclerosis narrowing of the arteries may be eligible for this study Participants will undergo MRI and intravascular ultrasound of the arteries immediately after their catheterization and angiography The additional imaging will add from 1 to 2 hours to the angiogram procedure
Angiography Using the sheaths already in place in the groin artery catheters flexible plastic tubes are placed inside the arteries in order to inject a contrast dye to take x-ray pictures Patients who had an angiogram of the leg artery as part of their medical care will not repeat this test
Intravascular ultrasound An anti-clotting drug called heparin is given through a vein to prevent clot formation Blood samples are taken during the test to see if more heparin is needed Special wires are used to guide the catheters to the proper location inside the arteries A special ultrasound catheter is advanced over one of these wires to the large artery that supplies blood to the legs X-rays are used to help the physician place the ultrasound in the correct location to take ultrasound pictures of the artery wall
Magnetic resonance imaging A special MRI catheter is advanced through the catheter in the groin With the catheter in place the patient is carried to a stretcher and moved into a long metal cylinder the MRI scanner for imaging During the scanning a contrast drug called gadolinium is injected into an arm vein to brighten the images The patient is able to speak through a microphone at all times to the person taking the pictures
angiography x-ray picture
intravascular ultrasound ultrasound from inside the artery
magnetic resonance imaging MRI from outside the body
MRI using an antenna to take pictures inside the arteries of the pelvis
Standard angiography shows blockages inside the artery but does not provide any information about the arterial wall itself New ways of looking at the artery walls with MRI and ultrasound may provide insight into how arteries cause disease
Patients 21 years of age and older who require catheterization and angiography of the heart kidney or leg arteries because of atherosclerosis narrowing of the arteries may be eligible for this study Participants will undergo MRI and intravascular ultrasound of the arteries immediately after their catheterization and angiography The additional imaging will add from 1 to 2 hours to the angiogram procedure
Angiography Using the sheaths already in place in the groin artery catheters flexible plastic tubes are placed inside the arteries in order to inject a contrast dye to take x-ray pictures Patients who had an angiogram of the leg artery as part of their medical care will not repeat this test
Intravascular ultrasound An anti-clotting drug called heparin is given through a vein to prevent clot formation Blood samples are taken during the test to see if more heparin is needed Special wires are used to guide the catheters to the proper location inside the arteries A special ultrasound catheter is advanced over one of these wires to the large artery that supplies blood to the legs X-rays are used to help the physician place the ultrasound in the correct location to take ultrasound pictures of the artery wall
Magnetic resonance imaging A special MRI catheter is advanced through the catheter in the groin With the catheter in place the patient is carried to a stretcher and moved into a long metal cylinder the MRI scanner for imaging During the scanning a contrast drug called gadolinium is injected into an arm vein to brighten the images The patient is able to speak through a microphone at all times to the person taking the pictures
Detailed Description:
Coronary artery disease remains the leading cause of death in the United States Disruption of atherosclerotic plaque is associated with acute coronary syndromes including myocardial infarction but culprit lesions are difficult to identify beforehand Animal models of atherosclerosis have proven limited In vivo plaque characterization might be useful both in plaque prognostication and in understanding human vascular biology One imaging modality high-resolution magnetic resonance imaging MRI has been shown feasible for plaque visualization and characterization but still has important limitations In this pilot study we hope to apply a new MRI modality using coils antennae that are inside the artery being studied to achieve superior imaging
This pilot study will examine whether intravascular arterial wall MRI can visualize the arterial wall with a higher spatial resolution than currently available techniques of intravascular ultrasound or conventional magnetic resonance imaging using surface receiver coils In particular we hope to image in high resolution for the first time the outer arterial wall adventitia which is not readily visualized MRI using intravascular coils may also enable the study of blood flow and contrast accumulation within arterial walls potentially key markers of plaque angiogenesis and vulnerability
This pilot study will examine whether intravascular arterial wall MRI can visualize the arterial wall with a higher spatial resolution than currently available techniques of intravascular ultrasound or conventional magnetic resonance imaging using surface receiver coils In particular we hope to image in high resolution for the first time the outer arterial wall adventitia which is not readily visualized MRI using intravascular coils may also enable the study of blood flow and contrast accumulation within arterial walls potentially key markers of plaque angiogenesis and vulnerability
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-H-0071 | None | None | None |