Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00026546
Status:
COMPLETED
Last Update Posted:
2019-12-12
First Post:
2001-11-09
Brief Title:
Behavior in Children With Attention Deficit Hyperactivity Disorder and in Healthy Volunteers
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Behavioral and Functional Neuroimaging Study of Inhibitory Motor Control
Status:
COMPLETED
Status Verified Date:
2018-10-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine how the brain controls motor activity in children with attention deficit hyperactivity disorder ADHD
The inability to control one s behavior is an important symptom of many psychiatric illnesses The stop signal paradigm which involves withholding a motor response to a go signal has proved useful in assessing uncontrolled behavior in children with ADHD and other disorders This study will use a stop signal paradigm in order to evaluate the ability of children with and without ADHD to control their motor behavior A magnetic resonance imaging MRI scan will be used to study how the brain works during specific activities
This study will evaluate the stop signal paradigm in three groups of people healthy children children with ADHD and healthy adults This study comprises two sub-studies a behavioral study in which participants perform simple activities and an MRI study
Participants will be asked to stop any over-the-counter medication 5 days before entering the behavioral or MRI study Children with ADHD will be asked to stop taking medication for ADHD 72 hours before the study All participants will have a medical history and a psychiatric evaluation for children both parents and children provide information for the assessment Participants in the MRI study will also have physical examinations and blood and urine tests All children will undergo intelligence tests and those with ADHD will have tests to confirm the diagnosis The parents of child participants will complete an autism screening questionnaire
The inability to control one s behavior is an important symptom of many psychiatric illnesses The stop signal paradigm which involves withholding a motor response to a go signal has proved useful in assessing uncontrolled behavior in children with ADHD and other disorders This study will use a stop signal paradigm in order to evaluate the ability of children with and without ADHD to control their motor behavior A magnetic resonance imaging MRI scan will be used to study how the brain works during specific activities
This study will evaluate the stop signal paradigm in three groups of people healthy children children with ADHD and healthy adults This study comprises two sub-studies a behavioral study in which participants perform simple activities and an MRI study
Participants will be asked to stop any over-the-counter medication 5 days before entering the behavioral or MRI study Children with ADHD will be asked to stop taking medication for ADHD 72 hours before the study All participants will have a medical history and a psychiatric evaluation for children both parents and children provide information for the assessment Participants in the MRI study will also have physical examinations and blood and urine tests All children will undergo intelligence tests and those with ADHD will have tests to confirm the diagnosis The parents of child participants will complete an autism screening questionnaire
Detailed Description:
The inability to exert appropriate inhibitory control over ones behavior is an important symptom of many psychiatric illnesses The stop signal paradigm which involves withholding a prepotent motor response to a signal has proved useful in assessing this deficit in children with a range of disorders particularly attention deficit hyperactivity disorder ADHD In order to adapt the paradigm for use in fMRI studies it is important to address two methodological issues 1 the substitution of a visual stop signal for the more commonly-employed auditory stop signal and 2 the fact that on the traditional stop task in which the subject withholds a motor response to the stop signal correct trials do not involve a motor response whereas incorrect trials do The latter problem can be addressed using the stop-change task in which the subject executes alternative motor responses to the stop and go signals The first aim of this protocol is to compare behavioral data from the stop and stop-change tasks in control adults control children and children with ADHD These data will be used to test the hypotheses that on each of these paradigms children with ADHD will show an inhibitory deficit compared to control children and control children will show an inhibitory deficit compared to control adults The second aim of the protocol is to conduct a pilot fMRI study of the stop and stop-change tasks in control adults The study has an event-related design and will test the hypotheses that ventral prefrontal activation will be greater during successful than unsuccessful stop or stop-change trials and that stop and stop-change trials will be associated with more anterior cingulate and right inferior frontal activation than will go trials
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-M-0036 | None | None | None |