Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00029484
Status:
COMPLETED
Last Update Posted:
2006-08-18
First Post:
2002-01-11
Brief Title:
Tai Chi Chih and Varicella Zoster Immunity
Sponsor:
National Center for Complementary and Integrative Health NCCIH
Organization:
National Center for Complementary and Integrative Health NCCIH
Study Overview
Official Title:
Tai Chi Chih and Varicella Zoster Immunity
Status:
COMPLETED
Status Verified Date:
2006-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A randomized control trial testing whether a relaxation response based intervention Tai Chi Chih will affect Varicella Zoster Virus VZV specific immunity measures of psychological adaptation and health function in the older adult
Detailed Description:
Both the incidence and severity of Herpes Zoster HZ or Shingles increase markedly with increasing age is a painful condition due to a decline in Varicella Zoster Virus VZV specific immunity Considerable evidence further shows that psychological stresses salient in the older adult correlate with impairments of cellular immunity
The investigators have observed that Varicella Zoster Immunity is always decreased in individuals with major depression Moreover our preliminary data indicates that the presence of depressive symptoms in older adults is associated with a decline of VZV responder cell frequency VZV-RCF Taken together the untoward effects of age and depressive symptoms on VZV immunity raise the question as to whether an alternative medicine intervention might augment VZV specific immunity in the older adult We have preliminarily shown that administration of a relaxation-response based intervention Tai Chi Chih TCC results in improvements in health functioning and VZV immunity in older adults as compared to controls TCC is a slow moving meditation comprised of twenty separate standardized movements for use in elderly populations
This proposed controlled clinical trial aims to 1 determine whether the practice of TCC for 16 weeks influences Varicella Zoster Virus VZV immunity 2 demonstrate that TCC can produce significant changes in psychological adaptation health behaviors and health functioning and well-being and 3 assess whether changes in psychological adaptation health behaviors and health functioning correlate with changes in VZV immunity following TCC in older adults
We hypothesize that this behavioral intervention that prioritizes treatment of excessive physiological arousal can influence ones affective state with effects on cellular immunity By standardization of training and practice schedules TCC offers an important advantage over prior relaxation response based therapies Focus on older adults at increase risk for HZ and assay of VZV specific cellular immunity has implications for understanding the impact of behavioral factors and an alternative medicine intervention on a clinically relevant endpoint and the ability of the immune system to respond to antigens of infectious pathogens
The investigators have observed that Varicella Zoster Immunity is always decreased in individuals with major depression Moreover our preliminary data indicates that the presence of depressive symptoms in older adults is associated with a decline of VZV responder cell frequency VZV-RCF Taken together the untoward effects of age and depressive symptoms on VZV immunity raise the question as to whether an alternative medicine intervention might augment VZV specific immunity in the older adult We have preliminarily shown that administration of a relaxation-response based intervention Tai Chi Chih TCC results in improvements in health functioning and VZV immunity in older adults as compared to controls TCC is a slow moving meditation comprised of twenty separate standardized movements for use in elderly populations
This proposed controlled clinical trial aims to 1 determine whether the practice of TCC for 16 weeks influences Varicella Zoster Virus VZV immunity 2 demonstrate that TCC can produce significant changes in psychological adaptation health behaviors and health functioning and well-being and 3 assess whether changes in psychological adaptation health behaviors and health functioning correlate with changes in VZV immunity following TCC in older adults
We hypothesize that this behavioral intervention that prioritizes treatment of excessive physiological arousal can influence ones affective state with effects on cellular immunity By standardization of training and practice schedules TCC offers an important advantage over prior relaxation response based therapies Focus on older adults at increase risk for HZ and assay of VZV specific cellular immunity has implications for understanding the impact of behavioral factors and an alternative medicine intervention on a clinically relevant endpoint and the ability of the immune system to respond to antigens of infectious pathogens
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None