Ignite Creation Date:
2024-05-05 @ 9:17 PM
Last Modification Date:
2024-10-26 @ 10:02 AM
Study NCT ID:
NCT00858676
Status:
UNKNOWN
Last Update Posted:
2012-07-18
First Post:
2009-03-09
Brief Title:
Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease AAA Trial
Sponsor:
Aichi Gakuin University
Organization:
Aichi Gakuin University
Study Overview
Official Title:
Multicenter Trial on Clinical Utility of Acarbose in Patients With Ischemic Heart Disease Accompanied by Abnormal Glucose Regulation
Status:
UNKNOWN
Status Verified Date:
2012-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of this trial is to investigate the effect of early treatment of glucose toxicity with acarbose a drug to control postprandial hyperglycemia on the occurence of cardiovascular events and the inhibition of atherosclerosis
Detailed Description:
Acarbose suppresses the postprandial increase in plasma glucose levels by inhibiting the activities of alpha-amylase and alpha-glucosidase involved in digestion and absorption of carbohydrates in the intestine A clinical study involving patients with type 2 diabetes demonstrated that acarbose decreased the post-load glucose level and improved glycosylated hemoglobin control A prospective study involving patients with impaired glucose tolerance IGT demonstrated that acarbose inhibited progression to type 2 diabetes and significantly reduced the risk of cardiovascular diseases It has also been reported that acarbose slows increase in the intima-media thickness and inhibits the progression of atherosclerosis A significant proportion of patients with acute coronary syndrome and those with stable angina pectoris suffer from diabetes or IGT and their prognosis is poor
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None