Ignite Creation Date:
2024-05-05 @ 9:16 PM
Last Modification Date:
2024-10-26 @ 10:02 AM
Study NCT ID:
NCT00855998
Status:
UNKNOWN
Last Update Posted:
2010-06-03
First Post:
2009-02-22
Brief Title:
Thymidine Kinase 1 in Risk Assessment for Hereditary Breast Ovarian Cancer
Sponsor:
Hadassah Medical Organization
Organization:
Hadassah Medical Organization
Study Overview
Official Title:
Thymidine Kinase 1 in Risk Assessment for Hereditary Breast Ovarian Cancer
Status:
UNKNOWN
Status Verified Date:
2009-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to compare the activity of Thymidine Kinase 1 in serum of two groups of woman at high and normal risk for breastovary cancer
Detailed Description:
Hereditary breastovarian cancer syndrome is associated with mutations in tumor suppressor BRCA1 and BRCA2 genes Products of these genes play an important role in the repair of DNA double-strand breaks Mutations in BRCA1 and BRCA2 genes could impair DNA repair In resting or G1 cells where the de novo synthesis of DNA precursors is absent the salvage pathway is the sole provider of deoxyribonucleotides to be used in DNA repair For this process a sufficient supply of deoxynucleotides and activity of Thymidine Kinase 1 are essential TK1 is an important component of adaptive response of cells to DNA damage Mutations in genes directly engaged in the DNA repair process could lead to the accumulation of DNA damage and in turn cause an adaptive cell reaction manifesting as permanently increased Thymidine Kinase 1 activity
A recently developed new high-sensitive assay DiviTum allows to investigate the contribution of this enzyme to DNA repair processes and to make a comparison of Thymidine kinase 1 activity in women with normal and impared DNA repair system
A recently developed new high-sensitive assay DiviTum allows to investigate the contribution of this enzyme to DNA repair processes and to make a comparison of Thymidine kinase 1 activity in women with normal and impared DNA repair system
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None